Keratin 3 Explained

Keratin 3 also known as cytokeratin 3 is a protein that in humans is encoded by the KRT3 gene.^{[1] [2]} Keratin 3 is a type II cytokeratin. It is specifically found in the corneal epithelium together with keratin 12.

Mutations in the KRT3 encoding this protein have been associated with Meesmanns Corneal Dystrophy.^[3]

Notes and References

1. Raimondi E, Moralli D, De Carli L, Ceratto N, Balzaretti M, Leube R, Collin C, Romano V . Assignment of the human cytokeratin 3 gene (KRT3) to 12q12-->q13 by FISH . Cytogenet. Cell Genet. . 66 . 3 . 162–3 . 1994 . 7510223 . 10.1159/000133690.
2. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . J. Cell Biol. . 174 . 2 . 169–74 . July 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
3. Irvine AD, Corden LD, Swensson O, Swensson B, Moore JE, Frazer DG, Smith FJ, Knowlton RG, Christophers E, Rochels R, Uitto J, McLean WH . Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy . Nat. Genet. . 16 . 2 . 184–7 . June 1997 . 9171831 . 10.1038/ng0697-184 . 24438634 .