Keratin 10 Explained

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene.^{[1] [2] [3]} Keratin 10 is a type I keratin.

Function

Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.^[3]

Interactions

Keratin 10 has been shown to interact with AKT1.^[4]

See also

• 34βE12 (keratin 903)

Further reading

• Yang JM, Nam K, Kim SW, etal . Arginine in the beginning of the 1A rod domain of the keratin 10 gene is the hot spot for the mutation in epidermolytic hyperkeratosis . J. Dermatol. Sci. . 19 . 2 . 126–33 . 1999 . 10098704 . 10.1016/S0923-1811(98)00055-3.
• Rasmussen HH, van Damme J, Puype M, etal . Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes . Electrophoresis . 13 . 12 . 960–9 . 1993 . 1286667 . 10.1002/elps.11501301199 . 41855774 .
• Korge BP, Gan SQ, McBride OW, etal . Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops . Proc. Natl. Acad. Sci. U.S.A. . 89 . 3 . 910–4 . 1992 . 1371013 . 10.1073/pnas.89.3.910 . 48354. 1992PNAS...89..910K . free .
• Tkachenko AV, Buchman VL, Bliskovsky VV, etal . Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats . Gene . 116 . 2 . 245–51 . 1992 . 1378806 . 10.1016/0378-1119(92)90521-P.
• Rothnagel JA, Dominey AM, Dempsey LD, etal . Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis . Science . 257 . 5073 . 1128–30 . 1992 . 1380725 . 10.1126/science.257.5073.1128. 1992Sci...257.1128R . 30648935 .
• Cheng J, Syder AJ, Yu QC, etal . The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes . Cell . 70 . 5 . 811–9 . 1992 . 1381287 . 10.1016/0092-8674(92)90314-3. 31906051 .
• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin . J. Infect. . 24 . 3 . 317–20 . 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4.
• Nazzaro V, Ermacora E, Santucci B, Caputo R . Epidermolytic hyperkeratosis: generalized form in children from parents with systematized linear form . Br. J. Dermatol. . 122 . 3 . 417–22 . 1990 . 2182100 . 10.1111/j.1365-2133.1990.tb08292.x. 9344745 .
• Darmon MY, Sémat A, Darmon MC, Vasseur M . Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression . Mol. Biol. Rep. . 12 . 4 . 277–83 . 1988 . 2448602 . 10.1007/BF00444680 . 4322605 .
• Zhou XM, Idler WW, Steven AC, etal . The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences . J. Biol. Chem. . 263 . 30 . 15584–9 . 1988 . 10.1016/S0021-9258(19)37628-8 . 2459124 . free .
• Rieger M, Franke WW . Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10 . J. Mol. Biol. . 204 . 4 . 841–56 . 1989 . 2464696 . 10.1016/0022-2836(88)90045-9 .
• van Dongen GA, Braakhuis BJ, Leyva A, etal . Anti-tumor and differentiation-inducing activity of N,N-dimethylformamide (DMF) in head-and-neck cancer xenografts . Int. J. Cancer . 43 . 2 . 285–92 . 1989 . 2465278 . 10.1002/ijc.2910430221 . 22052183 .
• Rogaev EI, Rogaeva EA, Ginter EK, etal . Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes . Nat. Genet. . 5 . 2 . 158–62 . 1994 . 7504553 . 10.1038/ng1093-158 . 9295678 .
• Rothnagel JA, Longley MA, Holder RA, etal . Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing . J. Invest. Dermatol. . 102 . 1 . 13–6 . 1994 . 7507150 . 10.1111/1523-1747.ep12371723. free .
• McLean WH, Eady RA, Dopping-Hepenstal PJ, etal . Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE) . J. Invest. Dermatol. . 102 . 1 . 24–30 . 1994 . 7507152 . 10.1111/1523-1747.ep12371726. free .
• Chipev CC, Yang JM, DiGiovanna JJ, etal . Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis . Am. J. Hum. Genet. . 54 . 2 . 179–90 . 1994 . 7508181 . 1918158 .
• Rothnagel JA, Fisher MP, Axtell SM, etal . A mutational hot spot in keratin 10 (KRT 10) in patients with epidermolytic hyperkeratosis . Hum. Mol. Genet. . 2 . 12 . 2147–50 . 1994 . 7509230 . 10.1093/hmg/2.12.2147 .
• Syder AJ, Yu QC, Paller AS, etal . Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity . J. Clin. Invest. . 93 . 4 . 1533–42 . 1994 . 7512983 . 10.1172/JCI117132 . 294170.
• Huber M, Scaletta C, Benathan M, etal . Abnormal keratin 1 and 10 cytoskeleton in cultured keratinocytes from epidermolytic hyperkeratosis caused by keratin 10 mutations . J. Invest. Dermatol. . 102 . 5 . 691–4 . 1994 . 7513736 . 10.1111/1523-1747.ep12374270. free .

Notes and References

1. Lessin SR, Huebner K, Isobe M, Croce CM, Steinert PM . Chromosomal mapping of human keratin genes: evidence of non-linkage . J Invest Dermatol . 91 . 6 . 572–8 . Jan 1989 . 2461420 . 10.1111/1523-1747.ep12477087. free .
2. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . J Cell Biol . 174 . 2 . 169–74 . Jul 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
3. Web site: Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris).
4. Paramio . J M . Segrelles C . Ruiz S . Jorcano J L . Nov 2001 . Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest . Mol. Cell. Biol. . 21 . 21 . 7449–59 . United States. 0270-7306. 11585925 . 10.1128/MCB.21.21.7449-7459.2001 . 99917 .