| Official Name: | Keowee Key, South Carolina |
| Settlement Type: | Census-designated place |
| Pushpin Map: | South Carolina#USA |
| Pushpin Label: | Keowee Key |
| Coordinates: | 34.8261°N -82.9183°W |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | South Carolina |
| Subdivision Type2: | County |
| Subdivision Name2: | Oconee |
| Area Footnotes: | [1] |
| Area Total Sq Mi: | 6.12 |
| Area Land Sq Mi: | 3.47 |
| Area Water Sq Mi: | 2.65 |
| Area Total Km2: | 15.85 |
| Area Land Km2: | 8.98 |
| Area Water Km2: | 6.86 |
| Population As Of: | 2020 |
| Population Density Km2: | 302.39 |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 948 |
| Postal Code Type: | ZIP Code |
| Postal Code: | 29676 (Salem) |
| Area Code: | 864 |
| Blank Name: | FIPS code |
| Blank Info: | 45-38058 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2812981 |
| Population Total: | 2716 |
| Unit Pref: | Imperial |
| Population Density Sq Mi: | 783.16 |
Keowee Key is a lakeside community and census-designated place (CDP) in Oconee County, South Carolina, United States. It is considered part of the Salem community. It was first listed as a CDP prior to the 2020 census with a population of 2,716.[2]
The CDP is on the eastern edge of Oconee County, on a peninsula extending into Lake Keowee, a reservoir on the Keowee River and Little River. The arm of the lake on the Little River borders the western side of the peninsula, while the Keowee River arm forms the eastern side and is the border with Pickens County. The two arms of the lake join via a small channel in the south part of the CDP; to the south, across the channel and outside the CDP, is the Oconee Nuclear Station power plant. The Keowee River is a south-flowing tributary of the Seneca River, a main tributary of the Savannah River.
South Carolina Highways 130 and 183 traverse the CDP. SC 130 (Stamp Creek Road) leads northwest 8miles to Salem, while SC 183 (Pickens Highway) leads west to Walhalla, the Oconee county seat. The two highways merge to form Rochester Highway, which leaves the CDP to the south. SC 130 continues south down Rochester Highway 10miles to Seneca, and SC 183 turns east and leads to Pickens.
| White alone (NH) | 2,604 | 95.88% | |
| Black or African American alone (NH) | 6 | 0.22% | |
| Native American or Alaska Native alone (NH) | 0 | 0.00% | |
| Asian alone (NH) | 13 | 0.48% | |
| Pacific Islander alone (NH) | 0 | 0.00% | |
| Some Other Race alone (NH) | 4 | 0.15% | |
| Mixed Race/Multi-Racial (NH) | 58 | 2.14% | |
| Hispanic or Latino (any race) | 31 | 1.14% | |
| Total | 2,716 | 100.00% |