| State: | KY |
| Type: | KY |
| Route: | 375 |
| Maint: | KYTC |
| Length Mi: | 3.3 |
| Length Round: | 3 |
| Length Ref: | [1] |
| Established: | 2020 |
| Direction A: | South |
| Terminus A: | southeast of Tompkinsville |
| Junction: | in Tompkinsville |
| Direction B: | North |
| Terminus B: | in Tompkinsville |
| Counties: | Monroe |
| Previous Type: | KY |
| Previous Route: | 374 |
| Next Type: | KY |
| Next Route: | 376 |
Kentucky Route 375 (KY 375) is a north–south state highway located entirely in Monroe County in south-central Kentucky.
Both of the route's termini are intersections with KY 163 southeast and north of Tompkinsville. It is one of the main thoroughfares in the city of Tompkinsville, with junctions with KY 1446 and then KY 63 and KY 100 in downtown Tompkinsville. At the intersection with KY 63 and KY 100, KY 375 turns on a northerly course to its second junction with KY 163 on the northern end of town.
In the 90 years since Kentucky's state highway system was established, KY 163 was the original north–south thoroughfare through the city of Tompkinsville. In 2020, KY 163 was rerouted to the new Tompkinsville Bypass, which was opened to traffic after almost three years since construction began in November 2017.[2] Once the bypass route was completed and opened to traffic in 2020, KY 163 was rerouted onto the bypass; the old alignment of KY 163 in Tompkinsville was redesignated as KY 375.[1]
The original KY 375 ran from KY 159 northeast of Falmouth southeast to KY 22 in Pendleton County. This route was removed from the state highway system by October 29, 1981, but was added back to the state highway system on May 4, 1987, as KY 3173.