Kenneth H. Wolfe Explained

Kenneth H. Wolfe should not be confused with Kenneth Wolf.

Ken Wolfe
Birth Name:Kenneth Henry Wolfe
Fields:Comparative genomics
Yeast genetics
Bioinformatics
Workplaces:University College Dublin
Trinity College Dublin
Indiana University Bloomington
Alma Mater:Trinity College Dublin (BA, PhD)
Thesis Title:Rates of nucleotide substitution in higher plants and mammals
Thesis Url:http://search.proquest.com/docview/301416258/
Thesis Year:1990
Doctoral Advisor:Paul M. Sharp[1]
Academic Advisors:Jeffrey D. Palmer
Awards:EMBO Member (2010)

Kenneth Henry Wolfe is an Irish geneticist and professor of genomic evolution at University College Dublin (UCD), Ireland.[2] [3]

Education

Wolfe was educated at Trinity College Dublin, where he was awarded Bachelor of Arts degree in genetics in 1986[4] followed by a PhD in 1990 for research investigating synonymous substitution in vascular plants and mammals supervised by Paul M. Sharp.[1] [5]

Research and career

Wolfe's research focuses on comparative genomics, yeast genetics and bioinformatics.[6] Work in his laboratory investigates the evolution of eukaryotic genomes and chromosome organisation. He is best known for his discovery that the genome of the yeast Saccharomyces cerevisiae underwent complete genome duplication about 100 million years ago, an event that is now known to be the result of hybridization between two divergent species. This finding reshaped our understanding both of yeast biology, and of mechanisms of genome evolution in eukaryotes. His subsequent discoveries of similar ancient genome duplications (paleopolyploidy) during human evolution, and in almost all families of flowering plants, led to the realisation that whole-genome duplication is widespread. His group also studies the origin and evolution of mating systems in yeasts, and the process of mating-type switching in which one cell type can change into another by moving or replacing a section of chromosome.

Wolfe was a postdoctoral researcher with Jeffrey D. Palmer at Indiana University Bloomington before returning to Ireland in 1992 to establish his research group in the genetics department of Trinity College Dublin,[7] where he remained for over 20 years. In 2013, he moved to University College Dublin's UCD School of Medicine and Conway Institute.[8] his most highly cited peer reviewed papers have been published in leading scientific journals including Nature,[9] [10] PNAS,[11] The Plant Cell,[12] [13] Genome Research[14] and Nature Reviews Genetics.[15]

Former doctoral students from the Wolfe lab include Mario A. Fares, Aoife McLysaght, Estelle Proux-Wéra and Cathal Seoighe.

Awards and honours

Wolfe was elected a Fellow of the Royal Society (FRS) in 2017,[16] a member of the Royal Irish Academy (MRIA) in 2000 and a member of the European Molecular Biology Organization (EMBO) in 2010.[17] In 2011 he served as president of the Society for Molecular Biology and Evolution (smbe.org).[18]

Notes and References

  1. PhD. Trinity College Dublin. Rates of nucleotide substitution in higher plants and mammals. Kenneth H.. Wolfe. 1990. 842511087. .
  2. , University College Dublin
  3. Web site: Kenneth H. Wolfe FTCD. 2000. ria.ie. Dublin. Anon. Royal Irish Academy. 2017-07-14. https://web.archive.org/web/20171211224237/https://www.ria.ie/kenneth-h-wolfe. 2017-12-11. dead.
  4. Ken Wolfe's
  5. Sharp. Paul M.. Cowe. Elizabeth. Higgins. Desmond G.. Desmond G. Higgins. Shields. Denis C.. Wolfe. Kenneth H.. Wright. Frank. Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; a review of the considerable within-species diversity. Nucleic Acids Research. 16. 17. 1988. 8207–8211. 0305-1048. 10.1093/nar/16.17.8207. 3138659 . 338553.
  6. Sherlock. Gavin. Schröder. Markus S.. Martinez de San Vicente. Kontxi. Prandini. Tâmara H. R.. Hammel. Stephen. Higgins. Desmond G.. Desmond G. Higgins. Bagagli. Eduardo. Wolfe. Kenneth H.. Butler. Geraldine. Multiple Origins of the Pathogenic Yeast Candida orthopsilosis by Separate Hybridizations between Two Parental Species. PLOS Genetics. 12. 11. 2016. e1006404. 1553-7404. 10.1371/journal.pgen.1006404. 27806045. 5091853 . free .
  7. Web site: Trinity College Dublin Genetics Department . www.tcd.ie.
  8. Web site: Ken Wolfe Profile . people.ucd.ie.
  9. Shields. Denis C.. 1997. Molecular evidence for an ancient duplication of the entire yeast genome. Nature. 387. 6634. 708–713. 10.1038/42711. 0028-0836. 9192896. Wolfe. Kenneth H.. 1997Natur.387..708W. 4307263. free.
  10. E. S.. Lander. Eric Lander. Linton . M.. Birren . B.. Nusbaum . C.. Zody . C.. Baldwin . J.. Devon . K.. Dewar . K.. Doyle . M. . Fitzhugh . W. . Funke . R. . Gage . D. . Harris . K. . Heaford . A. . Howland . J. . Kann . L. . Lehoczky . J. . Levine . R. . McEwan . P. . McKernan . K. . Meldrim . J. . Mesirov . J. P. . Jill P. Mesirov. Miranda . C. . Morris . W. . Naylor . J. . Raymond . C. . Rosetti . M. . Santos . R. . Sheridan . A. . Sougnez . C. . 29. Initial sequencing and analysis of the human genome. Nature. 2027.42/62798. 409. 6822. 860–921. 2001. 0028-0836. 11237011. 10.1038/35057062. 2001Natur.409..860L . free .
  11. Wolfe. K. H.. Li. W. H.. Sharp. P. M.. Rates of nucleotide substitution vary greatly among plant mitochondrial, chloroplast, and nuclear DNAs.. Proceedings of the National Academy of Sciences. 84. 24. 1987. 9054–9058. 0027-8424. 10.1073/pnas.84.24.9054. 3480529. 299690. 1987PNAS...84.9054W. free.
  12. Wolfe. 2004. Widespread Paleopolyploidy in Model Plant Species Inferred from Age Distributions of Duplicate Genes. The Plant Cell. 16. 7. 1667–1678. 10.1105/tpc.021345. 1040-4651. Blanc. Guillaume . Kenneth H.. 15208399 . 514152 .
  13. Blanc. Guillaume . Kenneth H.. Wolfe. Functional Divergence of Duplicated Genes Formed by Polyploidy during Arabidopsis Evolution. The Plant Cell. 16. 7. 2004. 1679–1691. 1040-4651. 10.1105/tpc.021410. 514153 . 15208398.
  14. Blanc. G.. A Recent Polyploidy Superimposed on Older Large-Scale Duplications in the Arabidopsis Genome. Genome Research. 13. 2. 2003. 137–144. 1088-9051. 10.1101/gr.751803. 12566392 . 420368. Karsten . Hokamp. Kenneth H. . Wolfe .
  15. Wolfe. Kenneth H.. Yesterday's polyploids and the mystery of diploidization. Nature Reviews Genetics. 2. 5. 2001. 333–341. 1471-0056. 10.1038/35072009. 11331899. 20796914.
  16. Web site: Professor Kenneth Wolfe FRS . 2017 . royalsociety.org . . London . Anon . dead . https://web.archive.org/web/20170505140928/https://royalsociety.org/people/kenneth-wolfe-13436/ . 2017-05-05 . One or more of the preceding sentences incorporates text from the royalsociety.org website where:
  17. Web site: Anon . 2010 . EMBO member: Kenneth H. Wolfe . Heidelberg . . people.embo.org . dead . https://web.archive.org/web/20170131223758/http://people.embo.org/profile/kenneth-h-wolfe . 2017-01-31 .
  18. Web site: SMBE Council members. smbe.org. Anon. 2017. 2017-09-22. https://web.archive.org/web/20171010090458/http://www.smbe.org/smbe/ABOUT/Council.aspx. 2017-10-10. dead.

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