Kelly A. Frazer Explained

Kelly A Frazer is a Professor of Pediatrics in the Medical School at the University of California, San Diego, Chief of the Division of Genome Information Sciences[1] and Director of the Institute for Genomic Medicine.[2]

Kelly A Frazer
Alma Mater:University of California, San Francisco
Doctoral Advisor:David R. Cox
Academic Advisors:Edward Rubin

Education

Frazer did her undergraduate studies at the University of California, Santa Cruz. She then attended the UCSF Medical Center at the University of California, San Francisco and received her PhD in 1993.

Research

Over the past thirty-three years Frazer has researched and discovered insights into the molecular underpinnings of a wide variety of human diseases and complex traits.[3] [4] As a postdoctoral fellow she and Edward Rubin pioneered cross-species DNA sequence comparisons between humans and mice resulting in the discovery of evolutionarily conserved non-coding regulatory sequences in the human genome.[5] [6] As Vice President of Genome Biology at Perlegen Sciences Frazer worked with David Cox and others to generate the content for the HapMap Phase II project[7] and determined that common structural variants are largely in linkage disequilibrium with common SNPs.[8] She joined UC San Diego as a faculty member in August 2009[9] and has developed novel methods for identifying and functionally characterizing regulatory variants underlying GWAS signals[10] [11] [12] [13] and has contributed to a greater understanding of mutational signatures in cancer.[14] [15]

External links

Notes and References

  1. Web site: Home - Division of Genome Information Sciences - UC San Diego Department of Pediatrics.
  2. Web site: Home . igm.ucsd.edu.
  3. Frazer. KA. Murray. SS. Schork. NJ. Topol. EJ. 19987352. 2009-04-10. Human Genetic Variation and Its Contribution to Complex Traits. Nature Reviews Genetics. 10. 4. 241–251. 10.1038/nrg2554. 1929382.
  4. Frazer. KA. September 2012. Decoding the human genome. Genome Research. 22. 9. 1599–1601. 10.1101/gr.146175.112. 22955971. 3431476. free.
  5. Loots. G. G.. Locksley. R. M.. Blankespoor. C. M.. Wang. Z. E.. Miller. W.. Rubin. E. M.. Frazer. K. A.. 2000-04-07. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science. 288. 5463. 136–140. 10.1126/science.288.5463.136. 0036-8075. 10753117. 2000Sci...288..136L.
  6. Frazer. KA. Pachter. L. Poliakov. A. Rubin. EM. Dubchak. I. 2004-07-01. VISTA: computational tools for comparative genomics. Nucleic Acids Research. 32. Web Server issue. W273–W279. 10.1093/nar/gkh458. 15215394. 441596. free.
  7. Frazer. KA. Ballinger. DG. Cox. DR. Hinds. DA. 2007-10-18. A Second Generation Human Haplotype Map of Over 3.1 Million SNPs. Nature. 449. 7164. 851–861. 10.1038/nature06258. 17943122. 2689609. 2007Natur.449..851F. 2027.42/62863. free.
  8. Hinds. DA. Kloek. AP. Jen. M. Chen. X. Frazer. KA. 24205661. 2005-12-04. Common deletions and SNPs are in linkage disequilibrium in the human genome. Nature Genetics. 38. 1. 82–85. 10.1038/ng1695. 16327809.
  9. Web site: UCSD Announces Chief of Division of Genome Information Sciences in Pediatrics.
  10. Harismendy. O. Notani. D. Song. X. Rahim. NG. Tanasa. B. Heintzman. N. 2011-02-10. 9p21 DNA Variants Associated With Coronary Artery Disease Impair Interferon-γ Signalling Response. Nature. 470. 7333. 264–268. 10.1038/nature09753. 21307941. 3079517. 2011Natur.470..264H.
  11. DeBoever. C. Li. H. Jakubosky. D. Benaglio. P. Reyna. J. Olson. KM. 2017-04-06. Large-scale profiling reveals the influence of genetic variation on gene expression in human induced pluripotent stem cells. Cell Stem Cell. 20. 4. 533–546.e7. 10.1016/j.stem.2017.03.009. 28388430. 5444918. free.
  12. Panapoulos. M. D'Antonio. M. Benaglio. P. Williams. R. Hashem. SI. 2017-04-11. iPSCORE: a resource of 222 iPSC lines enabling functional characterization of genetic variation across a variety of cell types. Stem Cell Reports. 8. 4. 1086–1100. 10.1016/j.stemcr.2017.03.012. 28410642. 5390244. free.
  13. Greenwald. WW. Li. H. Benaglio. P. Jakubosky. D. Matsui. H. Schmitt. A. 2019-03-05. Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression. Nature Communications. 10. 1. 1054. 10.1038/s41467-019-08940-5. 30837461. 6401380. 2019NatCo..10.1054G. free.
  14. DeBoever. C. Ghia. EM. Shepard. PJ. Rassenti. L. Barrett. CL. Jepsen. K. 2015-03-13. Transcriptome sequencing reveals potential mechanism of cryptic 3'splice site selection in SF3B1-mutated cancers. PLOS Computational Biology. 11. 3. e1004105. 10.1371/journal.pcbi.1004105. 25768983. 4358997. 2015PLSCB..11E4105D. free.
  15. D'Antonio. M. Tamayo. P. Mesirov. JP. Frazer. KA. 2016-07-19. Kataegis Expression Signature in Breast Cancer Is Associated With Late Onset, Better Prognosis, and Higher HER2 Levels. Cell Reports. 16. 3. 672–683. 10.1016/j.celrep.2016.06.026. 27373164. 4972030. free.

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