Keith Dalziel Explained

Birth Date:	24 August 1921
Birth Place:	Salford, England
Spouse:	Sallie Farnworth
Children:	2
Awards:	Fellow of the Royal Society, Professorial fellow of Wolfson College, Oxford
Fields:	Enzymes (especially alcohol dehydrogenase), kinetics
Workplaces:	Department of Biochemistry, University of Oxford

Professor Keith Dalziel F.R.S.^[1] (24 August 1921  - 7 January 1994) was a British biochemist.

Life

Dalziel was born in Salford, the youngest of four children of Gilbert and Edith Dalziel. His father, born in Dumfries, Scotland, worked as a mechanic, lorry driver and chauffeur. He was the first of his family to enter higher education. He married Sallie Farnworth in 1945, and the couple had two daughters, born in 1947 and 1952. He died on 7 January 1994. The name Dalziel is of Scottish origin and it is pronounced [dɪj'el] with only slightly more stress on the second syllable, essentially like the prefix in -lactic acid.

Career

Dalziel spent the greater part of his scientific career at the Department of Biochemistry of the University of Oxford. He worked primarily on liver alcohol dehydrogenases, and is well known in enzymology for his idiosyncratic way of representing the kinetic equations of two-substrate reactions.^{[2] [3]} He wrote the typical equation as follows:

([ E _{0} ])/(v) = \phi _{0} + (\phi _{A})/(+ [ A ]) (\phi _{B})/(+ [ B ]) (\phi _{AB})/([ A ][ B ])

for a reaction between A and B with rate v. The coefficients

\phi are known as Dalziel coefficients. This system has not been widely adopted. A more usual way of writing the same relationship (with the same symbols for the concentrations) would be as follows:v = (k _{0 [ E _{0} ][ A ][ B ]})/(K _{iA} K _{mB} + K _{mB} [ A ] + K _{mA} [ B ] + [ A ][ B ])

Here

K _{mA} and K _{mB} are the Michaelis constants (concentrations at half-saturation) for A and B at limiting (saturating) concentrations of B and A respectively, and K _{iA} (not the same as K _{mA} ) is a type of inhibition constant.

Dalziel was a professorial fellow of Wolfson College, and in 1975 was elected a Fellow of the Royal Society^[1]

Notes and References

1. Gutfreund . H. . 10.1098/rsbm.1996.0008 . Keith Dalziel. 24 August 1921 – 7 January 1994 . . 42 . 112–126 . 1996 . 770200. 11619329.
2. Dalziel . K. . Keith Dalziel. Engel . P. C. . Antagonistic homotropic interactions as a possible explanation of coenzyme activation of glutamate dehydrogenase . FEBS Letters . 1 . 5 . 349–352 . 1968 . 11945341 . 10.1016/0014-5793(68)80153-X. 26761011 .
3. Dalziel . K. . Keith Dalziel. A kinetic interpretation of the allosteric model of Monod, Wyman, and Changeux . FEBS Letters . 1 . 5 . 339–342 . 1968 . 11945338 . 10.1016/0014-5793(68)80150-4. free .