Kazichene Cove (Bulgarian: залив Казичене|zaliv Kazichene, in Bulgarian pronounced as /ˈzalif kɐˈzit͡ʃɛnɛ/) is a 2.2 km wide cove on the southeast side of Osmar Strait indenting for 1.3 km the northwest coast of Low Island in the South Shetland Islands, Antarctica. It is south of Lyutibrod Rocks and Fernandez Point, and north of Solnik Point.
The cove is named after the settlement of Kazichene in western Bulgaria.
Kazichene Cove is centred at -63.255°N -62.2278°W. British mapping in 2009.