Kathryn Moore Explained

Kathryn J. Moore
Fields:Atherosclerosis and Inflammation
Workplaces:Harvard Medical School
New York University Langone Medical Center
Alma Mater:McGill University
Thesis Title:Regulation of macrophage function during intracellular infection with Leishmania donovani.
Thesis Url:http://www.worldcat.org/oclc/1006638562
Thesis Year:1994
Doctoral Advisor:Greg Matlashewski
Known For:Atherosclerosis
Awards:National Institutes of Health R35 Outstanding Investigator AwardFellow of the National Academy of SciencesAmerican Heart Association Distinguished Scientist Award
Website:https://kathrynmoorelab.com/

Kathryn J. Moore is a Canadian-born American biomedical scientist and cell biologist. She is the Jean and David Blechman Professor of Cardiology and the founding director of the Cardiovascular Research Center[1] at the New York University Grossman School of Medicine. Moore's research considers the pathogenesis of atherosclerosis, with a focus on the identification of novel therapeutic targets. She was elected Fellow of the National Academy of Sciences in 2021.[2]

Early life and education

Kathryn Moore was born in Montreal, Quebec, Canada, where she attended McGill University. Moore studied microbiology, receiving her BSc (Distinction) from McGill University in 1989. She remained there for graduate studies, studying mechanisms by which the intracellular pathogen Leishmania donovani subverts macrophage microbicidal functions,[3] [4] [5] under the Canadian immunologist Greg Matlashewski. Moore was awarded her PhD in parasitology in 1994.[6]

Research and career

Moore joined the Harvard Medical School faculty as an Instructor in Medicine in 1999 and was promoted to Assistant Professor in 2002. Her early research focused on innate immune mechanisms of chronic inflammation in age-related diseases such as atherosclerosis and Alzheimer’s Disease.[7]

In 2009, Moore was recruited to the New York University Langone Medical Center, where she continued to focus on origins of cardiovascular and metabolic diseases, in particular the roles that chronic inflammation and lipid dysregulation play in these processes.[8] She contributed to seminal studies showing that cholesterol crystals in atherosclerotic plaques cause lysosomal damage that activates the NLRP3 inflammasome to promote the maturation and release of interleukin-1b.

Awards and honors

Notes and References

  1. Web site: Cardiovascular Research Center . 2022-11-02 . NYU Langone Health . en.
  2. Web site: 2021 NAS Election . 2021-05-03 . www.nasonline.org.
  3. Moore . K. J. . Labrecque . S. . Matlashewski . G. . 1993-05-15 . Alteration of Leishmania donovani infection levels by selective impairment of macrophage signal transduction . Journal of Immunology (Baltimore, Md.: 1950) . 150 . 10 . 4457–4465 . 0022-1767 . 8482844.
  4. Moore . K. J. . Turco . S. J. . Matlashewski . G. . Jan 1994 . Leishmania donovani infection enhances macrophage viability in the absence of exogenous growth factor . Journal of Leukocyte Biology . 55 . 1 . 91–98 . 10.1002/jlb.55.1.91 . 0741-5400 . 8283144.
  5. Moore . K. J. . Matlashewski . G. . 1994-03-15 . Intracellular infection by Leishmania donovani inhibits macrophage apoptosis . Journal of Immunology (Baltimore, Md.: 1950) . 152 . 6 . 2930–2937 . 0022-1767 . 8144893.
  6. Web site: Kathryn J. Moore . National Academy of Sciences Member Directory . 5 May 2023.
  7. Web site: New way discovered to block inflammation . 2024-07-31 . ScienceDaily . en.
  8. Web site: Kathryn J. Moore . 2024-07-31 . med.nyu.edu . en.
  9. Web site: EMF: New Scholar Award in Aging: Kathryn J. Moore Ph.D. . 2022-11-04 . www.ellison-med-fn.org.
  10. Web site: Claflin Distinguished Scholars Past Recipients . 2022-11-04 . MGH Executive Committee On Research.
  11. Web site: ATVB Special Recognition Awards . 2022-11-04 . professional.heart.org . en.
  12. Web site: Jeffrey M. Hoeg Arteriosclerosis, Thrombosis, and Vascular Biology Award for Basic Science and Clinical Research . 2022-11-04 . professional.heart.org . en.
  13. Web site: Professional Heart Daily . 2023-09-13 . professional.heart.org . en.
  14. Web site: Highly Cited Researchers . 2023-09-24 . publons.com.
  15. Web site: Highly Cited Researchers . 2023-09-24 . publons.com.
  16. Web site: George Lyman Duff Memorial Lecture . 2023-09-14 . professional.heart.org . en.
  17. Web site: Highly Cited Researchers . 2023-09-24 . publons.com.
  18. Web site: Kathryn J. Moore, Ph.D., FAHA, named the American Heart Association’s 2021 Distinguished Scientist in Arteriosclerosis, Thrombosis and Vascular Biology . 2023-09-14 . American Heart Association . en-us.
  19. Web site: 2022-03-16 . Gill Foundation Honors Excellence in Cardiovascular Medicine, Research . 2023-09-24 . UKNow.
  20. Web site: Internal Medicine The Gill Awards University of Kentucky College of Medicine . 2023-09-24 . medicine.uky.edu.
  21. Web site: Grand Prix de la Fondation Lefoulon-Delalande 2024 . 2024-06-05 . Fondation Lefoulon-Delalande . fr-FR.
  22. Web site: Cortigiano . Cameron . 2024-06-18 . Dr. Kathryn Moore awarded for cardiovascular physiology research . 2024-07-29 . www.beckersasc.com . en-gb.

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