| Kassena-Nankana District | |
| Settlement Type: | Former District |
| Pushpin Map: | Ghana |
| Pushpin Map Caption: | Location of Kassena-Nankana District within Upper East |
| Subdivision Type: | Country |
| Subdivision Name: |  Ghana |
| Subdivision Type1: | Region |
| Subdivision Name1: | Upper East |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Navrongo |
| Leader Title: | District Executive |
| Timezone: | GMT |
| Utc Offset: | +0 |
| Coordinates: | 10.8847°N -1.0903°W |
| Iso Code: | GH-UE-KN |
Kassena-Nankana District is a former district that was located in Upper East Region, Ghana. Originally created as an ordinary district assembly in 1988. However on 29 February 2008, it was split off into two new districts: Kassena-Nankana East District (which it was elevated to municipal district assembly status on 28 June 2012; capital: Navrongo) and Kassena-Nankana West District (capital: Paga). The district assembly was located in the western part of Upper East Region and had Navrongo as its capital town.