Importin subunit alpha-5 explained

Importin subunit alpha-5 is a protein that in humans is encoded by the KPNA1 gene.^[1]

Interactions

Importin subunit alpha-5 has been shown to interact with KPNB1^{[2] [3]} and UBR5.^[4]

Further reading

• Bukrinsky MI, Haffar OK . HIV-1 nuclear import: in search of a leader. . Front. Biosci. . 2 . 4. d578–87 . 2004 . 9366553 . 10.2741/A213. free .
• Bukrinsky MI, Haffar OK . HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. . Mol. Med. . 4 . 3 . 138–43 . 1998 . 9562972 . 2230352 . 10.1007/BF03401911.
• Kino T, Pavlakis GN . Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. . DNA Cell Biol. . 23 . 4 . 193–205 . 2004 . 15142377 . 10.1089/104454904773819789 .
• Bukrinsky MI, Sharova N, Dempsey MP, etal . Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. . Proc. Natl. Acad. Sci. U.S.A. . 89 . 14 . 6580–4 . 1992 . 1631159 . 49545 . 10.1073/pnas.89.14.6580 . 1992PNAS...89.6580B . free .
• Sharova N, Bukrinskaya A . p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells. . AIDS Res. Hum. Retroviruses . 7 . 3 . 303–6 . 1991 . 2064827 . 10.1089/aid.1991.7.303 .
• Di Marzio P, Choe S, Ebright M, etal . Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. . J. Virol. . 69 . 12 . 7909–16 . 1996 . 7494303 . 189735 . 10.1128/JVI.69.12.7909-7916.1995.
• Gallay P, Swingler S, Song J, etal . HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. . Cell . 83 . 4 . 569–76 . 1995 . 7585960 . 10.1016/0092-8674(95)90097-7 . 15536328 . free .
• Moroianu J, Hijikata M, Blobel G, Radu A . Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. . Proc. Natl. Acad. Sci. U.S.A. . 92 . 14 . 6532–6 . 1995 . 7604027 . 41552 . 10.1073/pnas.92.14.6532. 1995PNAS...92.6532M . free .
• Freed EO, Englund G, Martin MA . Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. . J. Virol. . 69 . 6 . 3949–54 . 1995 . 7745752 . 189124 . 10.1128/JVI.69.6.3949-3954.1995.
• Weis K, Mattaj IW, Lamond AI . Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. . Science . 268 . 5213 . 1049–53 . 1995 . 7754385 . 10.1126/science.7754385 . 1995Sci...268.1049W .
• O'Neill RE, Palese P . NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. . Virology . 206 . 1 . 116–25 . 1995 . 7831767 . 10.1016/S0042-6822(95)80026-3 .
• Gallay P, Swingler S, Aiken C, Trono D . HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. . Cell . 80 . 3 . 379–88 . 1995 . 7859280 . 10.1016/0092-8674(95)90488-3 . 15064293 . free .
• Moroianu J, Blobel G, Radu A . Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. . Proc. Natl. Acad. Sci. U.S.A. . 92 . 6 . 2008–11 . 1995 . 7892216 . 42412 . 10.1073/pnas.92.6.2008 . 1995PNAS...92.2008M . free .
• von Schwedler U, Kornbluth RS, Trono D . The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. . Proc. Natl. Acad. Sci. U.S.A. . 91 . 15 . 6992–6 . 1994 . 8041734 . 44324 . 10.1073/pnas.91.15.6992 . 1994PNAS...91.6992V . free .
• Heinzinger NK, Bukinsky MI, Haggerty SA, etal . The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. . Proc. Natl. Acad. Sci. U.S.A. . 91 . 15 . 7311–5 . 1994 . 8041786 . 44389 . 10.1073/pnas.91.15.7311 . 1994PNAS...91.7311H . free .
• Bukrinsky MI, Haggerty S, Dempsey MP, etal . A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. . Nature . 365 . 6447 . 666–9 . 1993 . 8105392 . 10.1038/365666a0 . 9524217 . 1993Natur.365..666B . 25678 .
• Dubrovsky L, Ulrich P, Nuovo GJ, etal . Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. . Mol. Med. . 1 . 2 . 217–30 . 1996 . 8529100 . 2229944 . 10.1007/BF03401569.
• Gallay P, Stitt V, Mundy C, etal . Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. . J. Virol. . 70 . 2 . 1027–32 . 1996 . 8551560 . 189908 . 10.1128/JVI.70.2.1027-1032.1996.
• Bukrinskaya AG, Ghorpade A, Heinzinger NK, etal . Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA. . Proc. Natl. Acad. Sci. U.S.A. . 93 . 1 . 367–71 . 1996 . 8552640 . 40239 . 10.1073/pnas.93.1.367 . 1996PNAS...93..367B . free .

Notes and References

1. Cortes P, Ye ZS, Baltimore D . RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1 . Proc Natl Acad Sci U S A . 91 . 16 . 7633–7 . Sep 1994 . 8052633 . 44456 . 10.1073/pnas.91.16.7633 . 1994PNAS...91.7633C . free .
2. Köhler . M . Speck C . Christiansen M . Bischoff F R . Prehn S . Haller H . Görlich D . Hartmann E . Nov 1999 . Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import . Mol. Cell. Biol. . 19 . 11 . 7782–91 . UNITED STATES. 0270-7306. 10523667 . 84838 . 10.1128/mcb.19.11.7782.
3. Percipalle . P . Clarkson W D . Kent H M . Rhodes D . Stewart M . Mar 1997 . Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import . J. Mol. Biol. . 266 . 4 . 722–32 . ENGLAND. 0022-2836. 9102465 . 10.1006/jmbi.1996.0801 .
4. Henderson . Michelle J . Russell Amanda J . Hird Samantha . Muñoz Marcia . Clancy Jennifer L . Lehrbach Gillian M . Calanni Sophina T . Jans David A . Sutherland Robert L . Watts Colin K W . Jul 2002 . EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response . J. Biol. Chem. . 277 . 29 . 26468–78 . United States. 0021-9258. 12011095 . 10.1074/jbc.M203527200 . free . 1885/64590 . free .