| Official Name: | Karuzi |
| Pushpin Map: | Burundi |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Burundi |
| Pushpin Relief: | y |
| Subdivision Type: | Country |
| Subdivision Name: | Burundi |
| Subdivision Name1: | Karuzi Province |
| Population As Of: | 2008 |
| Population Total: | 10317 |
| Population Density Km2: | auto |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Coordinates: | -3.1°N 40°W |
Karuzi, or Karusi, is a city located in eastern Burundi. It is the capital city of Karuzi Province.
On 8 June 2020, Burundian president Pierre Nkurunziza died in Karuzi from cardiac arrest.[1]
The Natwe Turashoboye Hospital is in the city of Karusi, in the south of the Buhiga Health District.It is a tertiary public hospital serving a population of 251,592 as of 2014.