| Karringmelk Spruit | |
| Pushpin Map: | South Africa |
| Subdivision Type1: | Country |
| Subdivision Name1: | South Africa |
| Subdivision Type2: | Province |
| Subdivision Name2: | Eastern Cape |
| Source1 Location: | Witteberge |
| Source1 Coordinates: | -30.7086°N 27.4642°W |
| Source1 Elevation: | 2500m (8,200feet) |
| Mouth Location: | South of Lady Grey, South Africa |
| Mouth Coordinates: | -30.9056°N 27.1244°W |
| Mouth Elevation: | 1400m (4,600feet) |
| River System: | Orange River |
The Karringmelk Spruit (literally "Buttermilk Spruit") is a tributary of the Kraai River in the Senqu area in the northeastern part of the Eastern Cape. It rises to the south of Wittenberg near Lesotho and flows as a stream southwestward through valleys and gorges east of the town of Lady Grey and further south to where it joins the Kraai River at -30.9056°N 27.1328°W.
The river is crossed by a historical railway line (at -30.8003°N 27.2467°W), and the Jan Kemp Vorster Bridge (1973) carries car traffic over the river in the direction of Barkly East, about 50 km away.
The Dutch name "karnmelk" means buttermilk, the slightly sour liquid left after butter has been churned, used in baking or consumed as a drink.