| Karnali Zone/Khasan | |
| Native Name: | कर्णाली अञ्चल/खसान |
| Settlement Type: | Zone |
| Mapsize: | 300px |
| Subdivision Type: | Country |
| Subdivision Name: |  Nepal |
| Subdivision Type1: | Region |
| Subdivision Name1: | Mid-Western |
| Subdivision Type2: | Zone |
| Subdivision Name2: | Karnali |
| Seat Type: | Capital |
| Blank Name Sec1: | Main language(s) |
| Timezone: | Nepal Time |
| Utc Offset: | +5:45 |
Karnali Zone (Nepali: [[:ne:कर्णाली अञ्चल|खसान अञ्चल]]) was one of the fourteen zones located in the Mid-Western Development Region of Nepal. The headquarters of Karnali Zone was Jumla.
Karnali Zone was one of the poorest and most remote regions of Nepal, not very accessible by road yet. There are airfields in all districts except Kalikot which is connected seasonally by roadways to Jumla Airport.
Karnali Zone was the largest zone of Nepal, with two national parks. Shey Phoksundo National Park Shey Phoksundo (with Phoksundo Lake—the deepest lake of Nepal), famous for the snow leopard, is Nepal's largest park with an area of 3,555 km2. Rara National Park surrounds Rara Lake—at 10.2 km2, Nepal's largest lake—known as the "Pearl of Nepal".
Karnali was divided into five districts; since 2015 these districts have been redesignated as part of Karnali Province.
| District | Type | Headquarters | Since 2015 part of Province |
|---|---|---|---|
| Dolpa | Mountain | Dunai | Karnali Province |
| Humla | Mountain | Simikot | |
| Jumla | Mountain | Jumla | |
| Kalikot | Mountain | Manma | |
| Mountain | Gamgadhi |