Karmella Haynes Explained

Karmella Haynes
Alma Mater:Washington University in St. Louis Ph.D (2006)
Florida A&M University B.S. (1999)
Thesis Year:2006
Birth Place:St. Louis, Missouri, U.S.
Doctoral Advisor:Sarah Elgin
Known For:Chromatin, Synthetic Biology, Epigenetics, Cancer
Awards:

Karmella Ann Haynes is a biomedical engineer and associate professor at the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University.[1] [2] She researches how chromatin is used to control cell development in biological tissue.

Early life and education

Haynes was born and raised in St. Louis.[3] She received her B.S. in biology from Florida A&M University (where she had received a full scholarship) in 1999 .[4] [5] While at Florida A&M, she participated in a summer research program working with Mary-Lou Pardue at Massachusetts Institute of Technology as part of the MIT Summer Research Program.[6] [7] [8]

Haynes did her graduate work in the lab of Sarah Elgin at Washington University in St. Louis. She received her Ph.D. in molecular genetics in 2006 for her work studying chromatin dynamics and epigenetics in Drosophila.[9] [10] [11] [12]

As a Howard Hughes Medical Institute fellow, she completed her first postdoctoral fellowship in teaching at Davidson College under the guidance of Laurie Heyer and Malcolm Campbell. During her time as a fellow, Haynes redesigned the undergraduate bioinformatics teaching course and won publication of the year from the Journal of Biological Engineering for her article Engineering bacteria to solve the Burnt Pancake Problem.[13] [14] [15] [16] [17] She was introduced to synthetic biology and became a member of Davidson's 2006 iGEM team.[18]

Haynes went on to complete a second postdoctoral fellowship in Pamela Silver's lab at Harvard Medical School where she leveraged her experience with chromatin dynamics and synthetic biology to create artificial transcription factors which activated genes based on histone methylation.[19]

Academic career and research

After her postdoctoral fellowships in 2011, Haynes started her lab in the School of Biological and Health Systems Engineering at Arizona State University (ASU).[20] [21] There, her lab focused on creating epigenetic machinery that can regulate DNA.[22] The proteins themselves are fusion transcription factors, which can target particular genes.[23] She hopes to increase the use of technology in therapeutics, working on tissue regeneration and customizable protein-based drugs.[24] In 2015 she was awarded a K01 grant to study the use of modular peptide motifs to build synthetic chromatin proteins that activate dormant therapeutic genes.[25] During her time at ASU, she was the faculty advisor for the ASU iGEM team.[26]

In 2018, Haynes moved to the W.H. Coulter Biomedical Engineering Department at Georgia Tech/Emory University.[27] During her time here, she founded the AfroBiotech conference and the Cold Spring Harbor Summer Course on Synthetic Biology.[28] [29] She was on the responsible conduct committee for IGEM in 2018 and 2019.[30] [31]

Public engagement

Haynes has appeared on PBS, talking about biotechnology and disease.[32] Alongside research, Haynes is an accomplished artist.[33] [34] In 2011, she painted her poster presentation for the Fifth International Meeting of Synthetic Biology (SB5.0) conference.[35] Her artwork is still on the walls at Harvard University. She is a member of the Building with Biology public engagement project.[36] She has been featured twice on Science Friday.[37]

Awards and honors

Professional memberships

Notable papers

As of August 16, 2020 based on Google Scholar citations:

External links

Notes and References

  1. Web site: Faculty Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. 2020-08-16. bme.gatech.edu.
  2. Web site: Karmella A. Haynes, PhD. 2020-08-16. winshipcancer.emory.edu.
  3. News: About. 2015-04-05. Karmella Haynes Artist. 2018-05-10. en-US.
  4. Web site: 2017 General Purpose. www.ncbi.nlm.nih.gov. en. 2018-05-10.
  5. Web site: 2020-06-23. The Cell Conductor. 2020-07-12. Grow by Ginkgo. en-US.
  6. Web site: Karmella Haynes: Turning the Dials. The Scientist. 2018-05-10.
  7. Web site: MIT Summer Research Program – General (MSRP) Office of Graduate Education. 2020-07-12.
  8. Web site: 2019-02-12. Karmella Haynes: Synthetic Biologist, Artist, Advocate, and Ultimate Puzzle Solver. 2020-07-13. Benchling. en-US.
  9. Haynes. Karmella A.. Caudy. Amy A.. Collins. Lynne. Elgin. Sarah C.R.. 2006-11-21. Element 1360 and RNAi Components Contribute to HP1-Dependent Silencing of a Pericentric Reporter. Current Biology. 16. 22. 2222–2227. 10.1016/j.cub.2006.09.035. 0960-9822. 1712676. 17113386. 2006CBio...16.2222H .
  10. Daer. René M.. Cutts. Josh P.. Brafman. David A.. Haynes. Karmella A.. 2017-03-17. The Impact of Chromatin Dynamics on Cas9-Mediated Genome Editing in Human Cells. ACS Synthetic Biology. 6. 3. 428–438. 10.1021/acssynbio.5b00299. 2161-5063. 5357160. 27783893.
  11. Nyer. David B.. Daer. Rene M.. Vargas. Daniel. Hom. Caroline. Haynes. Karmella A.. 2017-01-09. Regulation of cancer epigenomes with a histone-binding synthetic transcription factor. npj Genomic Medicine. 2. 10.1038/s41525-016-0002-3. 2056-7944. 5600530. 28919981.
  12. Haynes. Karmella A.. Silver. Pamela A.. 2011-08-05. Synthetic Reversal of Epigenetic Silencing. The Journal of Biological Chemistry. 286. 31. 27176–27182. 10.1074/jbc.C111.229567. 0021-9258. 3149311. 21669865. free .
  13. Web site: Time to Teach. 2018-05-10. HHMI.
  14. News: 2008-06-02. Living computers solve complex math puzzle. en. NBC News. 2018-05-10.
  15. News: 2016-03-30. Environment. en-GB. The Telegraph. https://web.archive.org/web/20160401234911/http://www.telegraph.co.uk/environment/. dead. 2016-04-01. 2018-05-10. 0307-1235.
  16. News: Calculating Bacteria: Real Computer Bugs?. en. NPR.org. 2018-05-10.
  17. Haynes. Karmella A.. Broderick. Marian L.. Brown. Adam D.. Butner. Trevor L.. Dickson. James O.. Harden. W. Lance. Heard. Lane H.. Jessen. Eric L.. Malloy. Kelly J.. 2008. Engineering bacteria to solve the Burnt Pancake Problem. Journal of Biological Engineering. En. 2. 1. 8. 10.1186/1754-1611-2-8. 1754-1611. 2427008. 18492232 . free .
  18. Web site: Davidson 2006 - 2006.igem.org. 2020-07-12. 2006.igem.org.
  19. Haynes. Karmella A.. Ceroni. Francesca. Flicker. Daniel. Younger. Andrew. Silver. Pamela A.. 2012. A Sensitive Switch for Visualizing Natural Gene Silencing in Single Cells. ACS Synthetic Biology. en. 1. 3. 99–106. 10.1021/sb3000035. 3331714. 22530199.
  20. News: Engineers from Day One. Issuu. 2018-05-10. en.
  21. Web site: Karmella Haynes. asu.pure.elsevier.com. en. 2018-05-10. https://web.archive.org/web/20180511081534/https://asu.pure.elsevier.com/en/persons/karmella-haynes/projects/. 2018-05-11. dead.
  22. Web site: Karmella Haynes-Farrell EBRC. dead. https://web.archive.org/web/20180511081505/https://www.ebrc.org/diversity-speaker/karmella-haynes-farrell. 2018-05-11. 2018-05-10. www.ebrc.org. en.
  23. Web site: BME Lecture Series: Karmella Haynes, Arizona State University The Henry Samueli School of Engineering at UC Irvine. 2018-05-10. engineering.uci.edu. en.
  24. Web site: 314: Dr. Karmella Haynes: Expressing Her Creativity Making Epigenetic Machinery and Designing Biological Devices - People Behind the Science Podcast. www.peoplebehindthescience.com. en-US. 2018-05-10. 2015-10-12.
  25. Karmella. Haynes. Synthetic chromatin for cancer research. Grantome. en.
  26. Web site: Team:Arizona State/Team - 2017.igem.org. 2017.igem.org. en. 2018-05-10.
  27. Web site: 2015-12-26. People. 2020-07-13. Haynes Lab Emory. en.
  28. Web site: 2019-03-06. AfroBiotech Conference 2019. 2020-07-13. www.aiche.org. en.
  29. Web site: Synthetic Biology CSHL. 2020-07-13. meetings.cshl.edu.
  30. Web site: Competition/Responsible Conduct - 2018.igem.org. 2020-07-13. 2018.igem.org.
  31. Web site: Competition/Rules of Conduct/Responsible Conduct - 2019.igem.org. 2020-07-13. 2019.igem.org.
  32. Web site: Career Profile: Synthetic Biologist Karmella Haynes. 2018-05-10. PBS LearningMedia. en.
  33. Web site: 2011-09-22. Combining art and science: Karmella Haynes interview. 2018-05-10. betterposters.blogspot.co.uk.
  34. Web site: Karmella Haynes - Artist. 2018-05-10. The Scientist.
  35. News: 2011-06-16. More art & science – hand painted poster at Synthetic Biology #synbio5 – by Karmella Haynes. en-US. Jonathan Eisen's Lab. 2018-05-10.
  36. Web site: Meet Our Scientists. 2018-05-10. www.buildingwithbiology.org.
  37. News: Karmella Haynes - Science Friday. en-US. Science Friday. 2018-05-10.
  38. Web site: Karmella Haynes. 2020-07-13. SB7.0. en-US.
  39. Web site: Our Members EBRC. 2020-07-13. en-US.
  40. Web site: Karmella Haynes, PH.D. - Assistant Professor at Emory University. 2020-07-13. The Ella Project. June 2018 . en-US.
  41. Web site: 2017-07-19. Karmella A. Haynes. 2020-07-13. www.aiche.org. en.
  42. Sun. Fang-Lin. Haynes. Karmella. Simpson. Cory L.. Lee. Susan D.. Collins. Lynne. Wuller. Jo. Eissenberg. Joel C.. Elgin. S. C. R.. September 2004. cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Molecular and Cellular Biology. 24. 18. 8210–8220. 10.1128/MCB.24.18.8210-8220.2004. 0270-7306. 515050. 15340080.
  43. Moe-Behrens. Gerd H. G.. Davis. Rene. Haynes. Karmella A.. 2013-01-25. Preparing synthetic biology for the world. Frontiers in Microbiology. 4. 5. 10.3389/fmicb.2013.00005. 1664-302X. 3554958. 23355834. free .
  44. Haynes. Karmella A.. Caudy. Amy A.. Collins. Lynne. Elgin. Sarah C.R.. 2006-11-21. Element 1360 and RNAi Components Contribute to HP1-Dependent Silencing of a Pericentric Reporter. Current Biology. 16. 22. 2222–2227. 10.1016/j.cub.2006.09.035. 0960-9822. 1712676. 17113386. 2006CBio...16.2222H .
  45. Haynes. Karmella A.. Silver. Pamela A.. 11842108. 2011-08-05. Synthetic Reversal of Epigenetic Silencing. Journal of Biological Chemistry. en. 286. 31. 27176–27182. 10.1074/jbc.C111.229567. 0021-9258. 21669865. 3149311. free.
  46. Haynes. Karmella A.. Silver. Pamela A.. 2009-11-30. Eukaryotic systems broaden the scope of synthetic biology. Journal of Cell Biology. en. 187. 5. 589–596. 10.1083/jcb.200908138. 19948487. 2806586. 0021-9525.

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