| Karl Heinrich Gräffe | |
| Birth Date: | 7 November 1799 |
| Birth Place: | Braunschweig, Principality of Brunswick-Wolfenbüttel (now Germany) |
| Death Place: | Zürich, Switzerland |
| Nationality: | German |
| Field: | Mathematics |
| Work Institutions: | University of Zurich |
| Alma Mater: | University of Göttingen |
| Thesis Title: | Commentatio historiam calculi variationum inde ab origine calculi differentialis atque integralis usque ad nostra tempora complectens |
| Thesis Url: | https://books.google.com/books?id=bTlSAAAAcAAJ |
| Thesis Year: | 1825 |
| Doctoral Advisor: | Bernhard Thibaut |
Karl Heinrich Gräffe (7 November 1799 – 2 December 1873) was a German mathematician, who was professor at the University of Zurich.
Gräffe's father migrated to North America, leaving the family business of jewelry in his hands. Even so, Gräffe succeeded, studying at night, entering the Carolineum of Brunswick in 1821. From 1823, he studied at the University of Göttingen with professors Gauss and Thibaut, doctorate in 1825.
In 1828 he was appointed professor of the Zurich Institute of Technology and, as of 1833, associate professor at the University of Zurich from the date of its creation. Simultaneously, also he was professor of the Obere Industrieschule.
Gräffe is known for having been the first to enunciate a method to approximate the roots of any polynomial, a method known today as the Dandelin-Gräffe method.