| Consort: | yes |
| Charles Emmanuel | |
| Landgrave of Hesse-Rotenburg | |
| Issue: | Victor, Landgrave of Hesse-Rotenburg Klotilde, Princess of Hohenlohe-Bartenstein |
| Spouse: | Princess Leopoldina of Liechtenstein |
| House: | House of Hesse-Kassel |
| Father: | Constantine of Hesse-Rotenburg |
| Mother: | Sophia of Starhemberg |
| Birth Date: | 5 June 1746 |
| Birth Place: | Langenschwalbach |
Charles Emmanuel, Landgrave of Hesse-Rotenburg (Karl Emanuel; 5 June 1746 – 23 March 1812) was landgrave of Hessen-Rotenburg between 1778 and 1812. He was named after his uncle Charles Emmanuel III of Sardinia, husband of his aunt Polyxena of Hesse-Rotenburg.
He was born in Langenschwalbach, the son of Constantine, Landgrave of Hesse-Rotenburg (24 May 1716 – 30 December 1778) and his first wife, Countess Maria Sophia Theresia Hedwigis Eva von Starhemberg (October 1722 – 12 December 1773), widow of William Hyacinth, Prince of Nassau-Siegen and sister of Georg Adam, Prince of Starhemberg.
Karl Emanuel married Princess Leopoldina Maria Anna Francisca de Paula Adelgunda of Liechtenstein (Vienna, 30 January 1754 – Frankfurt, 16 October 1823), daughter of Franz Josef I, Prince of Liechtenstein, on 1 September 1771 in Felsberg. The couple had two children.
Karl also had an illegitimate son by Lucie Juliane Amalie Struve (b. 1769), daughter of Johann Conrad Struve (d. 1782), Quartermaster from Braunschweig:
Karl's only descendants were from his illegitimate line.
He died in Frankfurt in 1812.