| Birth Place: | Vindeln, Sweden |
| Height: | 1.87m (06.14feet) |
| Weight: | 76kg (168lb) |
| Sport: | Athletics |
| Event: | 800 m, 1500 m |
| Club: | FIF Burälven IFK Umeå |
| Pb: | 800 m – 1:47.9 1500 m – 3:41.8 (1965) |
| Show-Medals: | yes |
Karl-Uno Olofsson (born 16 December 1940) is a retired Swedish middle-distance runner. He competed in 1500 m event at the 1964 Summer Olympics, but failed to reach the final. Olofsson became Nordic champion in the 1500 m (1965) and won the Swedish titles in the 800 m (1965), 1500 m (1963–65) and 4 × 1500 m relay (1965–67).