Kari Nadeau Explained

Kari Nadeau
Nationality:American
Thesis Title:Biochemical studies on protein folding chaperones : Hsp90 and cyclophilin ; and, On trypanosomal enzymes : trypanothione and glutationylspermidine synthetases
Thesis Url:http://id.lib.harvard.edu/alma/990062436760203941/catalog
Thesis Year:1995
Doctoral Advisor:Christopher T. Walsh
Workplaces:Harvard University
Stanford University
Known For:Allergy Prevention & Treatment

Kari C. Nadeau is the Chair of the Department of Environmental Health at Harvard School of Public Health and John Rock Professor of Climate and Population Studies.[1] She is adjunct professor at Stanford University in the Department of Pediatrics[2] and the co-chair of the Medical Societies Consortium for Climate Change and Health.[3] She practices Allergy, Asthma, Immunology in children and adults. She has published over 400+ papers, many in the field of climate change and health.[4] Her team focuses on quantifying health outcomes of solutions as they pertain climate change mitigation and adaptation at the local, regional, country, and global levels. Dr. Nadeau, with a team of individuals and patients and families, has been able to help major progress and impact in the clinical fields of immunology, infection, asthma, and allergy. Dr. Nadeau is a member of the National Academy of Medicine[5] and the U.S. EPA Children’s Health Protection Committee.[6]

For more than 30 years, she has devoted herself to understanding how environmental and genetic factors affect the risk of developing human disease. Her laboratory has been studying pollution effects on children and adults. Many of the health issues involving individuals and the public are increasing because of global warming, and extreme weather conditions. She oversees a team working with a multidisciplinary group of community leaders, engineers, scientists, lawyers, and policy makers. Dr. Nadeau was appointed as a member of the U.S. Federal Wildfire Commission in 2022.[7]

Dr. Nadeau works with other organizations and institutes across the world. She works with the WHO on a scoping review and report for health ministers and policy makers on wildland fires and/or air pollution: how to mitigate, adapt, and follow UN SDG’s to create resiliency and co-benefits in communities, especially LMICs.

Dr. Nadeau and her team perform research in the prevention and therapy of disease. She also launched four biotech companies,[8] [9] [10] and founded the Climate Change and Health Equity Task Force and started the Sustainability Health Seed Grant initiative and Climate Change and Health Fellowship program.[11] She also developed climate change and health courses, including a global masters class to teach Climate and Sustainability around the globe. She has served on the Scientific Advisory Board of the U.S. EPA.

She works as a member of the UNEA through Harvard to work on environmental health and planetary health governance and policy.[12] She is also a member of the Center for the Early Development of the Child scientific committee at Harvard.[13]

Dr. Nadeau is a Faculty Associate at The Salata Institute for Climate and Sustainability and works with the Harvard Global Health Initiative and with the FXB center for Health and Human Rights at Harvard University. She is the director of the Harvard Center for Climate, Health and the Global Environment. Through these programs Dr. Nadeau works directly with Environmental Justice, global,  regional, and local communities.

Her groundbreaking research has pioneered the field of allergies, asthma, and immunology, specifically in food allergies, pollution-induced asthma, and COVID-19. Dr. Nadeau’s studies have demonstrated that exposures to water and air pollution can modify the DNA of all ages of individuals and can lead to respiratory, allergic, and immune disorders.[14]

With her laboratory and team, Dr. Nadeau conducted research showing prescribed burns vs wildfire smoke was less harmful to communities.[15] She also was responsible for running the first clinical trial to treat multiple food allergies. Dr. Nadeau and her laboratory discovered novel mechanisms of STAT5a and STAT5b transcriptional factors to help understand the human immune system.[16]

Education

After graduating from Haverford College with a degree in biology,[17] Nadeau attended Harvard Medical School via the Medical Scientist Training Program (NIH), and received a PhD in biological chemistry and molecular pharmacology and an MD in 1995. She then started an internship and residency in pediatrics. From 1998 to 2002, she worked in the field of biopharmaceuticals and led clinical research to obtain FDA approval for two biologics in the field of Autoimmunity and Oncology, respectively. From 2003 to 2006, Nadeau was a pediatric resident and a fellow in Asthma, Allergy, and Immunology. She also did a postdoctoral fellowship in human immune tolerance mechanisms in asthma and allergy.[18] She received a certificate in Public Policy from the Harvard Kennedy School in 2022.

Career

In 2006, Nadeau was appointed to the Stanford University School of Medicine with appointments in Pediatrics and Otolaryngology. In 2016 she was named the Naddisy Foundation Professor of Pediatric Food Allergy, Immunology and Asthma endowed professorship under the Naddisy Family Foundation.[19] Nadeau has served as a reviewer for NIH Study Sections, and a member of the American Lung Association Medical Board, CA. She serves on the Environmental Health Policy committee for the American Thoracic Society and is a Fellow in the American Academy of Allergy, Asthma and Immunology and is a member of ASCI (American Society of Clinical Investigation).[20] Her laboratory focuses on the study of immunological mechanisms involved in the cause, diagnosis, and therapy for allergy and asthma.[21] In December, 2014 Sean Parker donated $24 million to Stanford to establish the Sean N. Parker Center for Allergy Research at Stanford University,[22] with Nadeau as the director.[23] [24]

In September 2020, Dr. Kari Nadeau published The End of Food Allergy: The First Program To Prevent and Reverse a 21st Century Epidemic with co-author Sloan Barnett.[25]

As of January 2023, Nadeau is Chair of the Department of Environmental Health at Harvard TH Chan School of Public Health. [26]

She is currently on the Scientific Advisory Board of Seed.

Research

Monitoring cells and responses in human immunotherapy and their effect on immune tolerance

Translational work (through conducting novel and innovative clinical studies to induce tolerance through immunotherapy) on Treg function and epigenetic changes.[27] [28] [29]  This research led to novel findings on markers of immune tolerance in clinical trial using food  oral immunotherapy for near fatal food allergies. Dr. Nadeau and her team study how immune cells respond to therapy using human blood and organoids.

Multiple Pollution Exposomics

Dr. Nadeau oversees collaborative teams examining plasma, cellular, and epigenetic markers that are affected by pollution in children, adolescents, and adults. Using well characterized cohorts across the world (for acute pollution exposure—i.e. wildfire) and in the Central Valley of California (for chronic exposure—i.e. Fresno is one of the highest ranked cities in the country for PM2.5 air pollution), Dr. Nadeau and her team have been able to perform innovative and impactful research that has helped shape public policy towards mitigating pollution and its effects on the public, (especially those at risk populations (like children) and the underserved (like Hispanic populations in the Central Valley of California).[30] [31] [32] [33]

Solutions in Climate Change Mitigation and Adaptation

Working with a team of dedicated multidisciplinary experts, Dr. Nadeau focuses on quantifying the health outcomes of solutions that have been implemented to address climate change. For example, her team studies whether certain diseases are lessened by switching from diesel to electric vehicles, from gas to electric stoves, from no to cooling devices, or from no biodiversity to greening a local area. She focuses her research on those communities that are inequitably exposed to climate change and extreme weather. [34] [35] [36] [37] [38]

Honors and awards

Media

Nadeau and her work have made a number of media appearances supporting food allergy awareness and research:

Notes and References

  1. Web site: 2023-01-21 . Kari C Nadeau . 2024-01-02 . Harvard T.H. Chan School of Public Health . en-US.
  2. Web site: Kari Nadeau, MD, PhD's Profile Stanford Profiles . 2024-01-08 . profiles.stanford.edu.
  3. Web site: Meet Our Team . 2024-01-08 . The Medical Society Consortium on Climate and Health (MSCCH) . en-US.
  4. Web site: Kari Nadeau . 2024-01-02 . connects.catalyst.harvard.edu.
  5. Web site: National Academy of Medicine Elects 100 New Members .
  6. Web site: CHPAC Committee Members . 21 July 2020 .
  7. Web site: Commission Members . 2024-01-02 . www.usda.gov . en.
  8. Web site: Alladapt Immunotherapeutics . 2024-01-09 . www.alladapt.com.
  9. Web site: IgGenix . 2024-01-09 . iggenix.com . en-US.
  10. Web site: Latitude Pharmaceuticals . 2024-01-09 . Latitude Pharmaceuticals . en-US.
  11. Web site: Our Climate and Human Health Fellowship . 2024-01-09 . www.bidmc.org . en-us.
  12. Web site: Environment Assembly . 2024-01-09 . Environment Assembly . en.
  13. Web site: Affiliated Faculty - Center on the Developing Child . 2024-01-09 . Center on the Developing Child at Harvard University . en-US.
  14. Aguilera . Juan . Han . Xiaorui . Cao . Shu . Balmes . John . Lurmann . Fred . Tyner . Tim . Lutzker . Liza . Noth . Elizabeth . Hammond . S. Katharine . Sampath . Vanitha . Burt . Trevor . Utz . P. J. . Khatri . Purvesh . Aghaeepour . Nima . Maecker . Holden . 2022-03-14 . Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ . Clinical Epigenetics . 14 . 1 . 40 . 10.1186/s13148-022-01254-2 . free . 1868-7083 . 8919561 . 35287715.
  15. Prunicki . Mary . Kelsey . Rodd . Lee . Justin . Zhou . Xiaoying . Smith . Edward . Haddad . Francois . Wu . Joseph . Nadeau . Kari . October 2019 . The Impact of Prescribed Fire versus Wildfire on the Immune and Cardiovascular Systems of Children . Allergy . 74 . 10 . 1989–1991 . 10.1111/all.13825 . 0105-4538 . 6801011 . 31002401.
  16. Jenks . Jennifer A. . Seki . Scott . Kanai . Takahiro . Huang . Jennifer . Morgan . Alexander A. . Scalco . Renata C. . Nath . Ruhi . Bucayu . Robert . Wit . Jan M. . Al-Herz . Waleed . Ramadan . Dina . Jorge . Alexander A. . Bacchetta . Rosa . Hwa . Vivian . Rosenfeld . Ron . August 2013 . Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells . Clinical Immunology . 148 . 2 . 227–236 . 10.1016/j.clim.2013.04.014 . 1521-6616 . 4169138 . 23773921.
  17. Web site: HAVERFORD-Spring-Summer-2013 .
  18. Nadeau . Kari C. . Callejas . Angel . Wong . Wendy B. . Joh . Jae Won . Cohen . Harvey J. . Jeng . Michael R. . December 2008 . Idiopathic neutropenia of childhood is associated with Fas/FasL expression . Clinical Immunology . 129 . 3 . 438–447 . 10.1016/j.clim.2008.08.006 . 1521-6616 . 4161459 . 18819843.
  19. Web site: Naddisy Foundation Professor of Pediatric Food Allergy, Immunology and Asthma . med.stanford.edu .
  20. Web site: Home . 2024-01-09 . The American Society for Clinical Investigation . en-US.
  21. Web site: The Nadeau Lab. Nadeaulab.stanford.edu. 2015-05-13.
  22. Web site: Sean Parker Center. Med.stanford.edu. 2015-05-13.
  23. Web site: Techcrunch. 17 December 2014 . Techcrunch.com . 3 May 2015.
  24. Web site: Why Sean Parker Gave $24 Million To Build A Stanford Allergy Research Center. Forbes.com . 3 May 2015.
  25. Book: The End of Food Allergy . 978-0593189511 . Nadeau . Kari . Barnett . Sloan . 2020 . Penguin .
  26. Web site: 2024-01-16 . Department of Environmental Health . 2024-01-02 . Department of Environmental Health . en-us.
  27. Kaushik . Abhinav . Dunham . Diane . Han . Xiaorui . Do . Evan . Andorf . Sandra . Gupta . Sheena . Fernandes . Andrea . Kost . Laurie Elizabeth . Sindher . Sayantani B. . Yu . Wong . Tsai . Mindy . Tibshirani . Robert . Boyd . Scott D. . Desai . Manisha . Maecker . Holden T. . 2022-11-04 . CD8+ T cell differentiation status correlates with the feasibility of sustained unresponsiveness following oral immunotherapy . Nature Communications . en . 13 . 1 . 6646 . 10.1038/s41467-022-34222-8 . 36333296 . 2041-1723. free . 9636180 .
  28. Prunicki . Mary . Cauwenberghs . Nicholas . Ataam . Jennifer Arthur . Movassagh . Hesam . Kim . Juyong Brian . Kuznetsova . Tatiana . Wu . Joseph C. . Maecker . Holden . Haddad . Francois . Nadeau . Kari . 2022-11-28 . Correction: Immune biomarkers link air pollution exposure to blood pressure in adolescents . Environmental Health . 21 . 1 . 117 . 10.1186/s12940-022-00916-1 . free . 1476-069X . 9703689 . 36443731. 2022EnvHe..21..117P .
  29. Allergy: Mechanistic insights into new methods of prevention and therapy . 2024-01-02 . Science Translational Medicine . 10.1126/scitranslmed.add2563 . 2023 . Akdis . Cezmi A. . Akdis . Mübeccel . Boyd . Scott D. . Sampath . Vanitha . Galli . Stephen J. . Nadeau . Kari C. . 15 . 679 . eadd2563 . 36652536 . 255966491 .
  30. Aguilera . Juan . Han . Xiaorui . Cao . Shu . Balmes . John . Lurmann . Fred . Tyner . Tim . Lutzker . Liza . Noth . Elizabeth . Hammond . S. Katharine . Sampath . Vanitha . Burt . Trevor . Utz . P. J. . Khatri . Purvesh . Aghaeepour . Nima . Maecker . Holden . 2022-03-14 . Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ . Clinical Epigenetics . 14 . 1 . 40 . 10.1186/s13148-022-01254-2 . free . 1868-7083 . 8919561 . 35287715.
  31. Jung . Youn Soo . Sampath . Vanitha . Prunicki . Mary . Aguilera . Juan . Allen . Harry . LaBeaud . Desiree . Veidis . Erika . Barry . Michele . Erny . Barbara . Patel . Lisa . Akdis . Cezmi . Akdis . Mubeccel . Nadeau . Kari . 2022-12-15 . Characterization and regulation of microplastic pollution for protecting planetary and human health . Environmental Pollution . 315 . 120442 . 10.1016/j.envpol.2022.120442 . 36272609 . 253037874 . 0269-7491.
  32. Goshua . Anna . Akdis . Cezmi A. . Nadeau . Kari C. . July 2022 . World Health Organization global air quality guideline recommendations: Executive summary . Allergy . 77 . 7 . 1955–1960 . 10.1111/all.15224 . 1398-9995 . 35060140. 240245347 .
  33. Movassagh . Hesam . Prunicki . Mary . Kaushik . Abhinav . Zhou . Xiaoying . Dunham . Diane . Smith . Eric M. . He . Ziyuan . Aleman Muench . German R. . Shi . Minyi . Weimer . Annika K. . Cao . Shu . Andorf . Sandra . Feizi . Amir . Snyder . Michael P. . Soroosh . Pejman . July 2023 . Proinflammatory polarization of monocytes by particulate air pollutants is mediated by induction of trained immunity in pediatric asthma . Allergy . 78 . 7 . 1922–1933 . 10.1111/all.15692 . 1398-9995 . 36929161. 257580769 .
  34. Agache . Ioana . Sampath . Vanitha . Aguilera . Juan . Akdis . Cezmi A. . Akdis . Mubeccel . Barry . Michele . Bouagnon . Aude . Chinthrajah . Sharon . Collins . William . Dulitzki . Coby . Erny . Barbara . Gomez . Jason . Goshua . Anna . Jutel . Marek . Kizer . Kenneth W. . May 2022 . Climate change and global health: A call to more research and more action . Allergy . 77 . 5 . 1389–1407 . 10.1111/all.15229 . 1398-9995 . 35073410. 246277357 .
  35. Perera . Frederica . Nadeau . Kari . 2022-06-16 . Solomon . Caren G. . Salas . Renee N. . Climate Change, Fossil-Fuel Pollution, and Children's Health . New England Journal of Medicine . en . 386 . 24 . 2303–2314 . 10.1056/NEJMra2117706 . 35704482 . 0028-4793.
  36. Lee . Alexandra S. . Aguilera . Juan . Efobi . Jo Ann . Jung . Youn Soo . Seastedt . Hana . Shah . Mihir M. . Yang . Emily . Konvinse . Katherine . Utz . Paul J. . Sampath . Vanitha . Nadeau . Kari C. . 2023-04-05 . Climate change and public health: The effects of global warming on the risk of allergies and autoimmune diseases: The effects of global warming on the risk of allergies and autoimmune diseases . EMBO Reports . 24 . 4 . e56821 . 10.15252/embr.202356821 . 1469-3178 . 36847605. 10074113 .
  37. Sarabu . Chethan . Deonarine . Andrew . Leitner . Stefano . Fayanju . Oluseyi . Fisun . Myroslava . Nadeau . Kari . 2022-11-14 . Climate change and health informatics: pilot survey of perspectives across the field . Journal of the American Medical Informatics Association . 29 . 12 . 2117–2123 . 10.1093/jamia/ocac199 . 1527-974X . 9667170 . 36264269.
  38. Akdis . Cezmi A. . Nadeau . Kari C. . November 2022 . Human and planetary health on fire . Nature Reviews Immunology . en . 22 . 11 . 651–652 . 10.1038/s41577-022-00776-3 . 36042380 . 1474-1741. 9425797 .
  39. Web site: Parker B. Francis Fellowship Program.
  40. Web site: AAAAI Award Recipients. Aaaai.org. 2015-05-13.
  41. Web site: McCormick and Gabilan Faculty Awards.
  42. Web site: Novel Immunological Approaches to Link Ambient Air Pollution Exposure to Health Outcomes Research Project Database Grantee Research Project ORD US EPA. cfpub.epa.gov. en. 2019-10-11.
  43. Web site: Council Members Collegium Internationale Allergologicum. www.ciaweb.org. 2019-10-11.
  44. Web site: Environmental Factor - January 2015: The impacts of air pollution on the immune system. factor.niehs.nih.gov. 2019-10-11.
  45. Web site: The ASCI's 2015 ballot results. ASCI. 22 March 2015 . 22 January 2018.
  46. Web site: 2018 Food Allergy Conference GRC. www.grc.org. 2018-01-15.
  47. Web site: Kari Nadeau, MD, PhD. 2019-09-05. Stanford Woods Institute for the Environment. en. 2019-10-11.
  48. Web site: Oct 17, 2022 . National Academy of Medicine Elects 100 New Members .
  49. shanjokgurung . 2023-07-20 . Review of the European Association of Allergy and Immunology (EAACI) Congress 2023 . Allergy & Immunology . en-GB . 2398-9130.
  50. News: The Allergy Buster. The New York Times. 7 March 2013 . 3 May 2015 . Thernstrom . Melanie .
  51. Web site: Funding a Cure for Food Allergies. May 2015 . Cnn.com. 3 May 2015.
  52. Web site: New Promise for People with Food Allergies. Huffingtonpost.com. 3 May 2015. 2015-03-04.
  53. Web site: The Human Rat in the Lab. Huffingtonpost.com. 3 May 2015. 2014-11-05.
  54. Web site: Allergy Free. Sixtyminutes.ninemsn.com.au. 3 May 2015.
  55. Web site: Food Allergy Treatments for Children Show Promise. 2 July 2014 . Nbcnews.com. 3 May 2015.
  56. Web site: How Giving Children Foods They Are Allergic To Can Cure Them, And Other Provocative Approaches In Evolutionary Medicine. Forbes.com. 6 May 2015.
  57. Web site: Retraining the body to lift the life sentence of food allergies. Video.pbs.org. 12 May 2015.
  58. Web site: New Hope for Kids With Multiple Food Allergies. https://web.archive.org/web/20180116004357/https://health.usnews.com/health-care/articles/2017-12-12/new-hope-for-kids-with-multiple-food-allergies. 2018-01-16. dead.
  59. News: HealthWatch: New Treatment To Help Kids With Multiple Food Allergies. 2017-12-13. 2018-01-15.
  60. Web site: Let's Focus on Food Allergy Prevention TEDx. YouTube.
  61. Web site: After On Episode 46. 9 April 2019.
  62. Web site: A peanut allergy cure? Big news on new treatments for 6 million kids.
  63. Web site: Allergy prevention: The fascinating method parents are turning to.
  64. Web site: Planetary Stewardship November 2023 . 2024-01-02 . TEDxBoston . en-US.

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