| Official Name: | Karene District |
| Subdivision Type: | Country |
| Subdivision Name: |  Sierra Leone |
| Subdivision Type1: | Province |
| Subdivision Name1: | North West |
| Seat Type: | Capital |
| Seat: | Kamakwie |
| Government Type: | District Council |
| Leader Party: | APC) |
| Leader Title: | District Council Chairman |
| Leader Name: | John Dito Kamara[1] |
| Population Total: | 285546[2] |
| Population As Of: | 2018 estimate |
| Timezone: | Greenwich Mean Time |
| Utc Offset: | -5 |
Karene District is a district in the North West Province, Sierra Leone. Karene is one of the sixteen districts that make up the Republic of Sierra Leone. The capital and largest city of Karene District is Kamakwie[3] Karene along with Falaba District are the two new districts of Sierra Leone formed in December 2017, after they were ratified by the Sierra Leone Parliament in the government of former president Ernest Bai Koroma[4]
The major economic activity in Karene is farming. The Temne people is the predominant majority ethnic group in Karene.
After the 2017 local administrative reorganization, Kerene District has made up of thirteen chiefdoms as the third level of administrative subdivision.
Prior to the 2017 local administrative reorganization, Libeisaygahun, Sanda Loko, Sanda Tenraren, Sella Limba and Tambakha Chiefdoms were formerly from Bombali District; and were Buya Romende, Debia and Sanda Magbolontor Chiefdoms were formerly from Port Loko District.