| Karen Sanford | |
| Birth Date: | 31 May 1932 |
| Birth Place: | Wayne, Alberta |
| Death Place: | Courtenay, British Columbia |
| Office1: | MLA for Comox |
| Term Start1: | 1972 |
| Term End1: | 1986 |
| Successor1: | Stan Hagen |
| Party: | British Columbia New Democratic Party |
Karen Elizabeth Sanford (May 31, 1932 - November 15, 2010) was a Canadian politician. She served as MLA for the Comox riding in the Legislative Assembly of British Columbia from 1972 until her defeat by Stan Hagen in the 1986 election, as a member of the British Columbia New Democratic Party.[1] She died of cancer in 2010.[2]