| Karen O'Donnell | |
| State House: | Massachusetts |
| District: | 10th Middlesex |
| Term Start: | 1993 |
| Term End: | 1995 |
| Successor: | Peter Koutoujian |
Karen O'Donnell was an American Democratic politician from Waltham, Massachusetts. She represented the 10th Middlesex district in the Massachusetts House of Representatives from 1993 to 1995.