Karen Miga Explained

Karen H. Miga
Birth Name:Karen Elizabeth Hayden
Workplaces:University of California, Santa Cruz
Thesis Title:A Genomic Definition of Centromeres in Complex Genomes
Thesis Url:http://www.worldcat.org/oclc/785816082
Thesis Year:2011
Doctoral Advisor:Huntington Willard
Known For:Telomere to Telomere Project

Karen Elizabeth Hayden Miga is an American geneticist who co-leads the Telomere-to-Telomore (T2T) consortium that released fully complete assembly of the human genome in March 2022.[1] She is an assistant professor of biomolecular engineering at the University of California, Santa Cruz and Associate Director of Human Pangenomics at the UC Santa Cruz Genomics Institute. She was named as "One to Watch" in the 2020 Nature's 10 and one of Time 100’s most influential people of 2022.[2]

Research and career

In 2012, Miga joined the laboratory of David Haussler at the University of California, Santa Cruz.[3] At UCSC she combined computational and experimental approaches.[4] There she leads the telomere-to-telomere (T2T) consortium,[5] a community based effort that seeks to fully sequence and assemble the human genome. Her research efforts make use of long-read sequencing strategies.[6] She makes use of the Oxford Nanopore Technologies MinION sequencer, which analyses DNA by detecting changes in current flow when DNA passes through nanopores in a membrane.

Miga is the director of the Human Pangenome Production Center that seeks to contribute to the next human pangenome reference map through the creation of 350 T2T diploid genomes.[7] This map will support the development of personalized therapeutics.

In 2022, Miga participated in the closing plenary session of the Clinton Global Initiative meeting,[8] where she discussed the future of equitable genomics research with former President Bill Clinton, U2 lead singer Bono, and Director-General of the World Health Organization (WHO) Tedros Ghebreyesus. 2023, Karen Miga was named a 2023 Searle Scholar[9] to study uncharted heterochromatin regions of the human genome.

Selected publications

Notes and References

  1. Web site: Researchers generate the first complete, gapless sequence of a human genome . 2023-02-07 . Genome.gov . en.
  2. Doudna, Jennifer (May 23, 2022). "The 100 Most Influential People of 2022: Michael Schatz, Karen Miga, Evan Eichler, and Adam Phillippy". Time. Retrieved 2023-10-18.
  3. Web site: Speaker - Cell Symposia: 20 Years of the Human Genome: from Sequence to Substance. 2020-12-20. www.cell-symposia.com.
  4. Web site: Isenberg. Sara. 2019-10-23. Are we there yet? Karen Miga on the Next Era of Genomics. 2020-12-20. Santa Cruz Tech Beat. en-US.
  5. Web site: Karen Miga VIB Conferences. 2020-12-20. www.vibconferences.be.
  6. Web site: Scientists achieve first complete assembly of human X chromosome. 2020-12-20. EurekAlert!. en.
  7. Web site: Dawn of good, fast and cheap human genome assembly. 2020-12-20. ScienceDaily. en.
  8. "Karen Miga discusses the future of equitable genomics research with Clinton, Bono" . news.ucsc.edu. Retrieved 2023-11-1
  9. https://searlescholars.org/ SEARLE SCHOLARS PROGRAM NAMES 15 SCIENTISTS AS SEARLE SCHOLARS FOR 2023

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