| Birth Date: | 29 May 1921 |
| Birth Place: | Vorup, Denmark |
| Death Date: | 29 February 2000 (aged 78) |
| Sport: | Canoe racing |
| Club: | Kano- og Kajakklubben Gudenaa, Randers |
| Show-Medals: | yes |
Karen Hoff (29 May 1921 – 29 February 2000) was a Danish sprint canoeist who competed in the late 1940s and early 1950s. She became the first female Olympic champion in the sport of canoeing when she won the gold medal in the K-1 500 m event at the 1948 Summer Olympics. Karen also won two medals at the ICF Canoe Sprint World Championships with a gold in K-2 500 m in 1948 and a silver in K-1 500 m in 1950.