| Karel Neffe Jr. | |
| Birth Date: | 21 February 1985 |
| Birth Place: | Prague |
| Sport: | Rowing |
Karel Neffe (born 21 February 1985 in Prague) is a Czech rower. He finished 5th in the men's coxless four at the 2008 Summer Olympics. His father Karel Neffe was a crew member of the Czechoslovak boat which won the bronze medal in the 1972 coxed four event.