| Karel Kesselaers | |
| Birth Date: | 3 September 1959 |
| Birth Place: | Oelegem, Belgium |
| Position: | Defender |
| Youthclubs1: | KSK Oelegem |
| Years1: | 1973–1977 |
| Years2: | 1977–1988 |
| Years3: | 1988–1989 |
| Years4: | 1989–1990 |
| Years5: | 1990–1991 |
| Years6: | 1991–1993 |
| Years7: | 1993–1994 |
| Clubs7: | KSK Oelegem |
| Caps3: | 12 |
| Goals3: | 1 |
| Nationalteam1: | Belgium Under-21 |
| Pcupdate: | 11 November 2007 |
| Ntupdate: | 11 November 2007 |
Karel Kesselaers (born 3 September 1959) is a Belgian former soccer player. In 1983, he was selected as player of the season by KV Mechelen in the same year of their promotion to the Belgian League. In 1987, he won the Belgian Cup, also with KV Mechelen, and in 1988 he won the European Cup Winners Cup with the team.