There were 10 karate events at the 2014 South American Games in Santiago, Chile: 5 men's events and 5 women's events. The events were held over March 7–9.[1]
Athletes in bold have qualified to compete at the 2015 Pan American Games in Toronto, Canada. Both Venezuela and Colombia elected to use the 2014 Central American and Caribbean Games as their qualifying event and thus are ineligible to qualify athletes here.
| 60 kg | Douglas Brose | Miguel Soffia | Jovanni Martinez Andres Rendon | |
| 67 kg | Andres Madera | José Ramírez | Julian Pinzas Israel Santana | |
| 75 kg | Franco Icasati | Esteban Espinoza | Leonardo Felizzola David Dubo | |
| 84 kg | Miguel Amargos | Diego Lenis | Jorge Acevedo ' Cesar Herrera | |
| +84 kg | Wellington Rodrigues | Angel Aponte | Franco Recouso Alejandro Mellado |
| 50 kg | Gabriela Bruna | Lilia Angulo | Aurimer Campos Merly Huamani | |
| 55 kg | Genesis Navarrrete | Jessy Reyes | Valéria Kumizaki Luciani Zorrilla | |
| 61 kg | Jacquelin Factos | Lina Gomez | Daniela Lepin Daniela Suarez | |
| 68 kg | Lorena Salamanca | Priscila Lazo | Carolina Santaya Natalia Ribeiro | |
| +68 kg | Yeisy Pina Ordaz | Veronica Lugo | Sayaka Osorio Isabela Dos Santos |