| Event: | Karate |
| Games: | 2001 Mediterranean Games |
| Prev: | 1997 |
| Next: | 2005 |
In the karate events at the 2001 Mediterranean Games in Tunis, the Open men's competition was won by Konstantinos Papadopoulos of Greece, and the Open women's competition by Yıldız Aras of Turkey. France came top of the medals table, with 5 gold medals.
| 60 kg |  Abdellatif Dini |  Francesco Luca Ortu |  Belhassen Gharbi  Driss Elmannani | |
| 65 kg | Alexandre Biamonti | Andrea Calzola | Sabeur Kriou  Ashraf Fenoun | |
| 70 kg | Rida Bel-Lhasen |  Óscar Vázquez Martins | Mohamed Elshemy Corrado Ferrara | |
| 75 kg | Wissem Arfaoui | Ahmed Elsayed |  Adnan Hadžić Stefanos Tetelenis | |
| 80 kg | Mohamed Monaam Hammouda | Salvatore Loria | Tarek Admane Yann Baillon | |
| + 80 kg | Seydina Balde | Hanabaal Jegham | Davide Benetello Arnel Kalušić | |
| Open | Konstantinos Papadopoulos | Predrag Stojadinov |  Okay Arpa David Felix |
| 50 kg | Hela Boudi | Michela Nanni | Mateja Bukovnik Heba Aly | |
| 55 kg | Estefania Garcia Romo | Roberta Sodero | Faten Heni Lana Sanja Susović | |
| 60 kg | Nathalie Leroy | Doaa Abdel Aziz | Noelia Fernandez Snežana Perić | |
| 65 kg | Gloria Casanova Rodriguez | Patricia Chereau | Sara Peković Roberta Minet | |
| + 65 kg | Theodora Dougeni | Laurence Fischer | Vanja Vrhovac Rym Draoui | |
| Open | Yıldız Aras | Theodora Dougeni | Slađana Mitić Nathalie Leroy |