Kallikrein 8 Explained

Kallikrein 8
Ec Number:	3.4.21.118
Cas Number:	171715-15-4

Kallikrein 8 (KLK8, PRSS19, human kallikrein 8, hK8, mK8, ovasin, tumor-associated differentially expressed gene 14, TADG-14, NP, neuropsin) is an enzyme.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys

The enzyme is activated by removal of an N-terminal prepropeptide.

Notes and References

1. Chen ZL, Yoshida S, Kato K, Momota Y, Suzuki J, Tanaka T, Ito J, Nishino H, Aimoto S, Kiyama H . Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus . The Journal of Neuroscience . 15 . 7 Pt 2 . 5088–97 . July 1995 . 7623137 . 6577896 . 10.1523/JNEUROSCI.15-07-05088.1995 .
2. Shimizu C, Yoshida S, Shibata M, Kato K, Momota Y, Matsumoto K, Shiosaka T, Midorikawa R, Kamachi T, Kawabe A, Shiosaka S . Characterization of recombinant and brain neuropsin, a plasticity-related serine protease . The Journal of Biological Chemistry . 273 . 18 . 11189–96 . May 1998 . 9556608 . 10.1074/jbc.273.18.11189 . free .
3. Rajapakse S, Ogiwara K, Takano N, Moriyama A, Takahashi T . Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins . FEBS Letters . 579 . 30 . 6879–84 . December 2005 . 16337200 . 10.1016/j.febslet.2005.11.039 . 2115/985 . free .
4. Kishi T, Cloutier SM, Kündig C, Deperthes D, Diamandis EP . Activation and enzymatic characterization of recombinant human kallikrein 8 . Biological Chemistry . 387 . 6 . 723–31 . June 2006 . 16800733 . 10.1515/BC.2006.091 .