Kallikrein 13 Explained

Kallikrein 13
Ec Number:	3.4.21.119
Cas Number:	342900-44-1

Kallikrein 13 (KLK13, kallikrein mK13, mGK-13, mK13, mKLK13, prorenin converting enzyme 1, PRECE-1, prorenin-converting enzyme, PRECE, proteinase P) is an enzyme.^{[1] [2] [3] [4]} This enzyme catalyses hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg- pair in the N-terminus, to yield mature renin.

This enzyme belongs in peptidase family S1A.

Notes and References

1. Nakayama K, Kim WS, Nakagawa T, Nagahama M, Murakami K . Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis . The Journal of Biological Chemistry . 265 . 34 . 21027–31 . December 1990 . 2250008 .
2. Kim WS, Hatsuzawa K, Ishizuka Y, Hashiba K, Murakami K, Nakayama K . A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization . The Journal of Biological Chemistry . 265 . 11 . 5930–3 . April 1990 . 2180937 .
3. Kikkawa Y, Yamanaka N, Tada J, Kanamori N, Tsumura K, Hosoi K . Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22) . Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology . 1382 . 1 . 55–64 . January 1998 . 9507064 . 10.1016/s0167-4838(97)00144-1 .
4. Yao C, Karabasil MR, Purwanti N, Li X, Akamatsu T, Kanamori N, Hosoi K . Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice . The Journal of Biological Chemistry . 281 . 12 . 7968–76 . March 2006 . 16423834 . 10.1074/jbc.m507705200 . free .