Kallidin Explained

Kallidin is a bioactive kinin formed in response to injury from kininogen precursors through the action of kallikreins.^[1]

Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. It can be converted to bradykinin by the aminopeptidase enzyme.

It can be a substrate for carboxypeptidase M and N.^[2]

Kallidin is identical to bradykinin with an additional lysine residue added at the N-terminal end and signals through the bradykinin receptor.

Notes and References

1. Book: Campbell, Duncan John . Handbook of Biologically Active Peptides . . 2013 . 978-0-12-385095-9 . Kastin . Abba J. . 2nd . Chapter 188 - Bradykinin Peptides . 10.1016/C2010-0-66490-X . https://www.sciencedirect.com/science/article/abs/pii/B9780123850959001883 . ScienceDirect.
2. Book: Stefan Offermanns. Walter Rosenthal. Encyclopedia of Molecular Pharmacology. 11 December 2010. 2008. Springer. 978-3-540-38916-3. 673–.