ZBTB33 explained

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene.^[1] This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[2]

NAMED by Dr.Juliet Daniel's, the KAISO gene was named after 'calypso' music popular in the Caribbeans, Trinidad & Tobago, e.t.c.

Interactions

ZBTB33 has been shown to interact with HDAC3,^[3] Nuclear receptor co-repressor 1^[3] and CTNND1.^[4]

Further reading

• Daniel JM, Reynolds AB . The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor . Molecular and Cellular Biology . 19 . 5 . 3614–23 . May 1999 . 10207085 . 84161 . 10.1128/mcb.19.5.3614.
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . Nov 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . Mar 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Prokhortchouk A, Hendrich B, Jørgensen H, Ruzov A, Wilm M, Georgiev G, Bird A, Prokhortchouk E . The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor . Genes & Development . 15 . 13 . 1613–8 . Jul 2001 . 11445535 . 312733 . 10.1101/gad.198501 .
• Daniel JM, Ireton RC, Reynolds AB . Monoclonal antibodies to Kaiso: a novel transcription factor and p120ctn-binding protein . Hybridoma . 20 . 3 . 159–66 . Jun 2001 . 11461664 . 10.1089/027245701750293484 .
• Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J . N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso . Molecular Cell . 12 . 3 . 723–34 . Sep 2003 . 14527417 . 10.1016/j.molcel.2003.08.008 . free .
• Kondapalli J, Flozak AS, Albuquerque ML . Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells . The Journal of Biological Chemistry . 279 . 12 . 11417–24 . Mar 2004 . 14699141 . 10.1074/jbc.M306057200 . free .
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A . From ORFeome to biology: a functional genomics pipeline . Genome Research . 14 . 10B . 2136–44 . Oct 2004 . 15489336 . 528930 . 10.1101/gr.2576704 .
• Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM, McCrea PD . Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin . Nature Cell Biology . 6 . 12 . 1212–20 . Dec 2004 . 15543138 . 10.1038/ncb1191 . 19404686 .
• Ruzov A, Dunican DS, Prokhortchouk A, Pennings S, Stancheva I, Prokhortchouk E, Meehan RR . Kaiso is a genome-wide repressor of transcription that is essential for amphibian development . Development . 131 . 24 . 6185–94 . Dec 2004 . 15548582 . 10.1242/dev.01549 . free . 20.500.11820/1328870e-099c-4bbd-8061-06b8b21f25ef . free .
• Kelly KF, Otchere AA, Graham M, Daniel JM . Nuclear import of the BTB/POZ transcriptional regulator Kaiso . Journal of Cell Science . 117 . Pt 25 . 6143–52 . Dec 2004 . 15564377 . 10.1242/jcs.01541 . 17008036 .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nature Biotechnology . 23 . 1 . 94–101 . Jan 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Soubry A, van Hengel J, Parthoens E, Colpaert C, Van Marck E, Waltregny D, Reynolds AB, van Roy F . Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment . Cancer Research . 65 . 6 . 2224–33 . Mar 2005 . 15781635 . 10.1158/0008-5472.CAN-04-2020 . free .
• Spring CM, Kelly KF, O'Kelly I, Graham M, Crawford HC, Daniel JM . The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin . Experimental Cell Research . 305 . 2 . 253–65 . May 2005 . 15817151 . 10.1016/j.yexcr.2005.01.007 .
• Arányi T, Faucheux BA, Khalfallah O, Vodjdani G, Biguet NF, Mallet J, Meloni R . The tissue-specific methylation of the human tyrosine hydroxylase gene reveals new regulatory elements in the first exon . Journal of Neurochemistry . 94 . 1 . 129–39 . Jul 2005 . 15953356 . 10.1111/j.1471-4159.2005.03173.x . free .
• Defossez PA, Kelly KF, Filion GJ, Pérez-Torrado R, Magdinier F, Menoni H, Nordgaard CL, Daniel JM, Gilson E . The human enhancer blocker CTC-binding factor interacts with the transcription factor Kaiso . The Journal of Biological Chemistry . 280 . 52 . 43017–23 . Dec 2005 . 16230345 . 10.1074/jbc.M510802200 . free .

Notes and References

1. Web site: Entrez Gene: ZBTB33 zinc finger and BTB domain containing 33.
2. Web site: ZBTB33 zinc finger and BTB domain containing 33 [Homo sapiens (human)] - Gene - NCBI]. www.ncbi.nlm.nih.gov. 2016-03-22.
3. Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J . N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso . Molecular Cell . 12 . 3 . 723–34 . Sep 2003 . 14527417 . 10.1016/j.molcel.2003.08.008 . free .
4. Daniel JM, Reynolds AB . The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor . Molecular and Cellular Biology . 19 . 5 . 3614–23 . May 1999 . 10207085 . 84161 . 10.1128/mcb.19.5.3614.