| Kaikhosro I Jaqeli | |
| Reign: | 1498–1500 |
| Predecessor: | Qvarqvare II |
| Successor: | Mzetchabuki |
| Succession: | Atabeg of Samtskhe |
| Dynasty: | Jaqeli |
| Father: | Qvarqvare II Jaqeli |
| Issue: | Qvarqvare III Jaqeli |
| Birth Place: | 1443 |
| Death Date: | 1500 |
| Religion: | Orthodox Christianity |
Kaikhosro I Jaqeli (Georgian: ქაიხოსრო I ჯაყელი; 1443–1500) was a Prince and Atabeg of Samtskhe-Saatabago, member of the Jaqeli family and son of Qvarqvare II. His reign lasted from 1498 to 1500. According to Kaikhosro's contemporaries, he was a wise and educated ruler. He held peace with the other Georgian kingdoms:Kartli, Kakheti and Imereti. Kaikhosro with king Alexander I of Kakheti and Constantine of Kartli agreed to assist first Safavid shah Ismail in destroying Aq Koyunlu rule in Persia.[1] Atabeg Kaikhosro died in 1500 and was succeeded by his younger brother Mzetchabuk Jaqeli.