Kai Simons Explained

Kai Simons
Birth Place:Helsinki, Finland
Nationality:Finnish
Fields:biochemistry, cell biology
Workplaces:Rockefeller University, University of Helsinki, EMBL, MPI-CBG, Lipotype GmbH
Education:University of Helsinki (MD), Rockefeller University (postdoctoral fellowship)
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Academic Advisors:Lennard Philipson, John Tooze, James Watson, Linus Pauling
Doctoral Students:Stephen Fuller
Notable Students:Dietrich Suck
Known For:lipid rafts, trans-Golgi network
Spouse:Carola Simons
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Children:3; Mikael, Katja, Matias
Website:http://www.lipotype.com

Kai Simons is a Finnish professor of biochemistry and cell biology and physician, living and working in Germany. He introduced the concept of lipid rafts, and coined the term trans-Golgi network. He is the co-founder and co-organizer of the European Molecular Biology Laboratory and European Molecular Biology Organization, and initiated the foundation of Max Planck Institute of Molecular Cell Biology and Genetics.

Early life and education

Kai Simons is the son of a physics professor. His father convinced him to study medicine, though he originally wanted to study physics. While studying at the University of Helsinki, Simons spent a summer internship in the Stockholm laboratory of Bengt Samuelsson[1] There, he studied mechanisms of vitamin B12 absorption. He worked with other students to organize a campaign to fight taeniasis, a disease common in eastern Finland where eating raw fish is popular.

After completing his MD in 1964, he began a postdoctoral fellowship at Rockefeller University in New York City, where he worked between 1966 and 1967 on blood serum protein polymorphism.

Career

Simons returned to Helsinki in 1967, where he began working as a junior investigator for the Finnish Medical Research Council at the University of Helsinki.[2] He became a group leader in 1972 and was a biochemistry professor in 1971–79 at the medical faculty of this university At first, he continued his work on serum proteins. Next, together with Leevi Kääriäinen and Ossi Renkonen, he started a research team – later joined by Ari Helenius, his first PhD student and later a post doctoral researcher who became Simons' brother-in-law. After a one-month stay in MRC Laboratory for Molecular Biology in Cambridge, the group started investigating a Semliki Forest virus, introduced to Simons by Kääriäinen.

In 1975 Simons went to Heidelberg, Germany, as one of the EMBL group leaders. Together with Ari Helenius he helped to develop EMBL, headed at this time by John Kendrew. In years 1982–1998 Simons was a coordinator of the Cell Biology Program there. During this time he for the first time he introduced the concept of lipid rafts,[3] as well as coined the term trans-Golgi network and proposed its role in protein and lipid sorting.[4]

In 1999 he took part in setting up ELSO (later incorporated into EMBO), which later he presided over.[5]

He was one of the initiators of establishing and building Max Planck Institute of Molecular Cell Biology and Genetics in Dresden (Germany), where he moved. Formally from 1998 (beginning of MPI-CBG construction) and from 2000 he was one of five institute's directors and also a group leader there.[6] He was a director (1998–2006) and a group leader (until 2012).[7] [8] Since 2006 he is a "director emeritus".

He is the co-founder and co-owner of Lipotype GmbH.[9] >

In 2012 he started-up a biotech company Lipotype GmbH, where he is a CEO.

Research

Early in his career, Simons pursued research in the field of medical biochemistry. Both his master's thesis and postgraduate research focused on vitamin B12 absorption.[10] [11] After returning from his post-doc scholarship he continued research on vitamin B12 as well as on blood plasma proteins, but soon started investigating Semliki Forest virus, focusing on its membrane and its lipid composition and their role in the virus budding and its transport, as the model for lipid and protein secretion.[12] [13] [14] [15] During this period, Simons also investigated the application of detergents in biochemistry with a special attention to their role in biological membrane research.[16]

The virus lifecycle and how it uses components of vesicular pathways while shuttling to the cell surface, turned Simons' attention toward vesicular transport pathways and cell polarization. Applying epithelial model cells – MDCK (Madin-Darby canine kidney), he investigated lipid transport, protein sorting and their role in polarizing cells.[17] [18]

In these studies, he described the role of the trans-Golgi network (TGN) in protein and lipid sorting according to their destination. In his works from 1988, together with Gerit van Meer,[19] [20] Simons proposed the existence of lipid microdomains in cell membranes for the first time. Such microdomains differ in their composition from the surrounding membrane and have special functions. Simons coined the term 'lipid rafts' to describe these microdomains. This concept was developed over the years to be presented more fully in 1997 in Nature journal by Simons and Ikonen. This paper became one of the most frequently cited works in the field of membrane research. Other Simons' paper, on role of lipid rafts in the signal transduction[21] is second highest cited work and Simons is fourth highest cited scientist in the field of signal transduction. Kai Simons was also recognized by ISI Web of Knowledge, as one of the most cited scientist ever.

In subsequent years, Simons continued to work on the role of lipid rafts, and more generally lipids, in cell polarization and protein sorting.[22] He was interested also in the role of lipids and protein sorting in neurodegenerative diseases, especially in Alzheimer's disease.[23] [24]

His scientific record includes more than 350 scientific articles, mostly in the field of biochemistry, molecular organization of the cell, and biochemistry and physiology of a cell membrane.

Considering his work from years 1996–2007 tracked until May 2009, Simons was 12. in the list of the most frequently cited scientists in the field cell biology with 90 articles and 16,299 citations.[25]

Honours and awards

Kai Simons honours and awards include:[26]

Kai Simons was and is also a member of numerous societies, committees and organisations, as well as an editor for several scientific journals.

Personal life

He is married to Carola Simons and a father of three.

External links

Notes and References

  1. Web site: ASCB Members Profile Archives – Kai Simons. 13 August 2009. The American Society for Cell Biology. https://web.archive.org/web/20070715061747/http://www.ascb.org/index.cfm?navid=110&id=1331&tcode=nws3. 15 July 2007. 27 July 2016.
  2. Web site: Kai Simons. MPI CBG Research Group -: Group Leader. Max Planck Institute of Molecular Cell Biology and Genetics. 28 July 2016. https://web.archive.org/web/20160927180635/https://www.mpi-cbg.de/research-groups/current-groups/kai-simons/group-leader.html. 27 September 2016. dead.
  3. Simons K, Ikonen E . Functional rafts in cell membranes . Nature . 387 . 6633 . 569–72 . 1997 . 9177342 . 10.1038/42408 . 1997Natur.387..569S . 4359503 .
  4. Griffiths G, Simons K . The trans Golgi network: sorting at the exit site of the Golgi complex . Science . 234 . 4775 . 438–43 . 1986 . 2945253 . 10.1126/science.2945253. 1986Sci...234..438G .
  5. Gransalke. Kathleen. 2014. There Are No Easy Solutions. Lab Times. 4. 34–37. 1864-2381. 27 July 2016. https://web.archive.org/web/20160806074002/http://www.labtimes.org/epaper/LT_14_04.pdf. 6 August 2016. dead.
  6. Simons. Kai. 29 December 2008. Kai Simons: membrane master. The Journal of Cell Biology. 183. 7. 1180–1181. 10.1083/jcb.1837pi. 1540-8140. 2606959. 19114590.
  7. Web site: MPI-CBG: Directors. Max Planck Institute of Molecular Cell Biology and Genetics. 26 July 2016.
  8. Web site: MPI-CBG: Alumni. Max Planck Institute of Molecular Cell Biology and Genetics. 26 July 2016.
  9. Web site: Everything you should know ABOUT US. Lipotype GmbH. 26 July 2016.
  10. Grasbeck. R.. Runeberg. L.. Simons. K.. 12 December 1959. Intrinsic factor and radiovitamin B12 excretion in rats. Acta Physiologica Scandinavica. 47. 370–374. 0001-6772. 13828995.
  11. Grasbeck. R.. Simons. K.. Sinkkonen. I.. 1 January 1962. Purification of intrinsic factor and vitamin B12 binders from human gastric juice. Annales Medicinae Experimentalis et Biologiae Fenniae. 40(Suppl 6). 1–24. 0003-4479. 13949889.
  12. Renkonen O, Gahmberg CG, Kaariainen L, Simons K . Envelope of Semliki Forest virus as membrane model . Biochem. J. . 128 . 1 . 20P–21P . 1972 . 5085567 . 1173622 . 10.1042/bj1280020pb.
  13. Renkonen O, Kääriäinen L, Gahmberg CG, Simons K . Lipids of Semliki Forest virus and of host cell membranes . Biochem. Soc. Symp. . 35 . 407–22 . 1972 . 4614812 .
  14. Simons K, Garoff H . The budding mechanisms of enveloped animal viruses . J. Gen. Virol. . 50 . 1 . 1–21 . 1980 . 6255080 . 10.1099/0022-1317-50-1-1 . free .
  15. Simons K, Warren G . Semliki Forest virus: a probe for membrane traffic in the animal cell . Adv. Protein Chem. . 36 . 79–132 . 1984 . 6382965 . 10.1016/S0065-3233(08)60296-X. Advances in Protein Chemistry . 9780120342365 . 7173159 .
  16. Helenius A, Simons K . Solubilization of membranes by detergents . Biochim. Biophys. Acta . 415 . 1 . 29–79 . 1975 . 1091302 . 10.1016/0304-4157(75)90016-7.
  17. Simons K, Fuller SD . Cell surface polarity in epithelia . Annu. Rev. Cell Biol. . 1 . 243–88 . 1985 . 3939606 . 10.1146/annurev.cb.01.110185.001331 .
  18. Simons K . Membrane traffic in an epithelial cell line derived from the dog kidney . Kidney Int. Suppl. . 23 . S201–10 . 1987 . 2831424 .
  19. van Meer G, Simons K . Lipid polarity and sorting in epithelial cells . J. Cell. Biochem. . 36 . 1 . 51–8 . 1988 . 3277985 . 10.1002/jcb.240360106 . 1874/294292 . 32086669 . free .
  20. Simons K, van Meer G . Lipid sorting in epithelial cells . Biochemistry . 27 . 17 . 6197–202 . 1988 . 3064805 . 10.1021/bi00417a001. 1874/293951 . free .
  21. Simons. K.. Toomre. D.. 1 October 2000. Lipid rafts and signal transduction. Nature Reviews. Molecular Cell Biology. 1. 1. 31–39. 10.1038/35036052. 1471-0072. 11413487. 10914632.
  22. Klemm. Robin W.. Ejsing. Christer S.. Surma. Michal A.. Kaiser. Hermann-Josef. Gerl. Mathias J.. Sampaio. Julio L.. de Robillard. Quentin. Ferguson. Charles. Proszynski. Tomasz J.. 18 May 2009. Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network. The Journal of Cell Biology. 185. 4. 601–612. 10.1083/jcb.200901145. 1540-8140. 2711577. 19433450.
  23. Rajendran. Lawrence. Honsho. Masanori. Zahn. Tobias R.. Keller. Patrick. Geiger. Kathrin D.. Verkade. Paul. Simons. Kai. 25 July 2006. Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proceedings of the National Academy of Sciences of the United States of America. 103. 30. 11172–11177. 10.1073/pnas.0603838103. 0027-8424. 1544060. 16837572. 2006PNAS..10311172R. free.
  24. Rajendran. Lawrence. Schneider. Anja. Schlechtingen. Georg. Weidlich. Sebastian. Ries. Jonas. Braxmeier. Tobias. Schwille. Petra. Schulz. Jörg B.. Schroeder. Cornelia. 25 April 2008. Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting. Science . 320. 5875. 520–523. 10.1126/science.1156609. 1095-9203. 18436784. 2008Sci...320..520R. 5500387.
  25. Neumann. Ralf. 2009. Publication Analysis 1996–2007. Cell Biology. Lab Times. 5. 42–44. 1864-2381. 27 July 2016.
  26. Web site: Academy of Europe: Simons, Kai. Academia Europaea. 26 July 2016.
  27. Web site: Kai Simons. Robert Koch Gold Medal 2016. 2016. Robert Koch Gold Medal 2016. Robert-Koch-Stiftung. 26 July 2016.

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