Kahn Sagol Maccabi Explained

The Kahn-Sagol-Maccabi for Research and Innovation
Native Name:Hebrew: מכון קאהן-סגול-מכבי למחקר ולחדשנות (Hebrew)
Type:Medical research
Established:2016
Country:Israel

The Kahn-Sagol-Maccabi (KSM) for Research and Innovation (in Hebrew: מכון קאהן-סגול-מכבי למחקר ולחדשנות) is the Research and Innovation Center of Maccabi Healthcare Services.[1]

History

Founded in 2016 by Maccabi Health Services with the key support of Morris Kahn and Sami Sagaol, KSM promotes excellence in medical research.[2]

It wasa formerly headed by Prof. Varda Shalev and is currently headed by Dr. Tal Patalon.[3]

Activities and services

Medical studies

KSM Center strives to enhance healthcare systems through independent research and partnerships with international researchers,[4] academic institutions, pharmaceutical companies, start-ups and technology firms.[5] [6]

Since its inception, the center has conducted hundreds of studies,[7] resulting in the development of tools for both patients and healthcare providers.[8] These studies have influenced medical policies in several countries, particularly during the COVID-19 pandemic.[9]

Notable studies conducted under KSM's auspices include:

Medical database

KSM's research activities are based on independent efforts, as well as the extensive medical knowledge and database of Maccabi Health Services.[21] This database, compiled over three decades and anonymized, encompasses digital records of 2.7 million insured individuals.[22]

In addition to its in-house research,[23] the Center offers global researchers access to conduct studies, analyses [30] and medical prediction,[24] based on this comprehensive database.[25]

KSM's innovation and big data department leverages databases and artificial intelligence technologies,[26] [27] facilitating a wide range of research opportunities, analysis and medical prediction.[28]

Biobank

The KSM Center has established the Tipa BioBank,[29] Israel's largest biobank[30] housing over a million genetic samples for research purposes.[31]

The purpose of this initiative is to develop tools for early disease detection through genetic[32] and biological studies.[33] A central feature of this effort is the creation of a repository of biological samples (e.g., blood, urine, etc.), enabling researchers to investigate how genetic profiles influence disease risk and treatment.[34]

Main publications

Notes and References

  1. https://www.ksminnovation.com/ The Kahn-Sagol-Maccabi (KSM) Institute for Research and Innovation
  2. Web site: Kahn Sagol Maccabi . Guidestar . 9 November 2023.
  3. https://www.maccabi4u.co.il/32342-he/Maccabi.aspx Big data unit
  4. Neesha Salian, SEHA and Israel’s leading HMO announce collaboration in research and digital health development, Gulf Business, 13 July 2022
  5. https://www.accesswire.com/721905/Maccabis-KSM-Research-and-Innovation-Center-Announces-Partnership-with-Rhino-Health-to-Facilitate-Healthcare-Data-Collaborations Maccabi’s KSM Research and Innovation Center Announces Partnership with Rhino Health to Facilitate Healthcare Data Collaborations
  6. https://www.360dx.com/cancer/prognomiq-maccabi-health-collaborating-cancer-biomarker-development PrognomiQ, Maccabi Health Collaborating on Cancer Biomarker Development
  7. https://www.ksminnovation.com/publications/ Professional publications
  8. News: Rubinstein . Carrie . Small-Big Data: A Healthcare Revolution In The Making . 26 October 2023 . . 9 September 2022.
  9. 10.1016/j.jpeds.2023.02.016 . Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents . 2023 . Patalon . Tal . Saciuk . Yaki . Perez . Galit . Peretz . Asaf . Ben-Tov . Amir . Gazit . Sivan . The Journal of Pediatrics . 257 . 36870558 . 9981270 .
  10. 10.1016/S2666-5247(23)00103-9 . Hybrid immunity against reinfection with SARS-CoV-2 following a previous SARS-CoV-2 infection and single dose of the BNT162b2 vaccine in children and adolescents: A target trial emulation . 2023 . Gazit . Sivan . Saciuk . Yaki . Perez . Galit . Peretz . Asaf . Ben-Tov . Amir . Stuart . Elizabeth A. . Patalon . Tal . The Lancet Microbe . 4 . 7 . e495–e505 . 37062294 . 10101759 .
  11. 35157493 . 2022 . Gazit . S. . Shlezinger . R. . Perez . G. . Lotan . R. . Peretz . A. . Ben-Tov . A. . Herzel . E. . Alapi . H. . Cohen . D. . Muhsen . K. . Chodick . G. . Patalon . T. . The Incidence of SARS-CoV-2 Reinfection in Persons with Naturally Acquired Immunity with and Without Subsequent Receipt of a Single Dose of BNT162b2 Vaccine: A Retrospective Cohort Study . Annals of Internal Medicine . 175 . 5 . 674–681 . 10.7326/M21-4130 . 8855786 .
  12. Dynamics of Naturally Acquired Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2 in Children and Adolescents . 10.1016/j.jpeds.2023.02.016 . 2023 . Patalon . Tal . Saciuk . Yaki . Perez . Galit . Peretz . Asaf . Ben-Tov . Amir . Gazit . Sivan . The Journal of Pediatrics . 257 . 36870558 . 9981270 .
  13. van Boven . Michiel . van Dorp . Christiaan H. . Westerhof . Ilse . Jaddoe . Vincent . Heuvelman . Valerie . Duijts . Liesbeth . Fourie . Elandri . Sluiter-Post . Judith . van Houten . Marlies A. . Badoux . Paul . Euser . Sjoerd . Herpers . Bjorn . Eggink . Dirk . de Hoog . Marieke . Boom . Trisja . Wildenbeest . Joanne . Bont . Louis . Rozhnova . Ganna . Bonten . Marc J. . Kretzschmar . Mirjam E. . Bruijning-Verhagen . Patricia . 3. Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study . PLOS Computational Biology . 20 . 1 . 29 January 2024 . 1553-7358 . 38285727 . 10852262 . 10.1371/journal.pcbi.1011832 . free . e1011832. 10.1101/2023.06.02.23290879.
  14. 10.1038/s41467-022-30884-6 . Waning effectiveness of the third dose of the BNT162b2 mRNA COVID-19 vaccine . 2022 . Patalon . Tal . Saciuk . Yaki . Peretz . Asaf . Perez . Galit . Lurie . Yoav . Maor . Yasmin . Gazit . Sivan . Nature Communications . 13 . 1 . 3203 . 35680872 . 9184525 . 2022NatCo..13.3203P .
  15. Prunas . Ottavia . Warren . Joshua L. . Crawford . Forrest W. . Gazit . Sivan . Patalon . Tal . Weinberger . Daniel M. . Pitzer . Virginia E. . 2022 . Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel . Science . 375 . 6585 . 1151–1154 . 2022Sci...375.1151P . 10.1126/science.abl4292 . 9261115 . 35084937.
  16. 10.3390/v15091968. free . BNT162b2 mRNA COVID-19 Vaccine Effectiveness in Patients with Coeliac Disease Autoimmunity: Real-World Data from Mass Vaccination Campaign . 2023 . Ben-Tov . Amir . Lebwohl . Benjamin . Banon . Tamar . Chodick . Gabriel . Kariv . Revital . Assa . Amit . Gazit . Sivan . Patalon . Tal . Viruses . 15 . 9 . 1968 . 37766374 . 10534420 .
  17. 10.3390/microorganisms11041042. free . Mpox Patient Journey in Israel . 2023 . Patalon . Tal . Perez . Galit . Saciuk . Yaki . Refaeli . Ziva . Gazit . Sivan . Microorganisms . 11 . 4 . 1042 . 37110465 . 10145053 .
  18. 10.3390/v15112261. free . An Outbreak of Parvovirus B19 in Israel . 2023 . Patalon . Tal . Saciuk . Yaki . Trotzky . Daniel . Pachys . Gal . Ben-Tov . Amir . Segal . Yaakov . Gazit . Sivan . Viruses . 15 . 11 . 2261 . 38005937 . 10674631 .
  19. 10.1002/aur.2869 . Late diagnosis of autism spectrum disorder—Journey, parents' concerns, and sex influences . 2023 . Davidovitch . Michael . Gazit . Sivan . Patalon . Tal . Leitner . Yael . Rotem . Ran S. . Autism Research . 16 . 2 . 294–301 . 36495248 . 254561408 .
  20. 10.2217/fon-2023-0176 . Real-world outcomes of patients with metastatic endocrine-responsive breast cancer receiving palbociclib-based combinations . 2023 . Moser . Sarah Sharman . Mazursky . Orr Friedman . Shalev . Hadas . Apter . Lior . Chodick . Gabriel . Siegelmann-Danieli . Nava . Future Oncology . 19 . 21 . 1473–1483 . 37529919 . free .
  21. Valo Health, KSM research and innovation center and Valo health announce first of its kind multiyear collaboration to spearhead preventive care and personalized medicine for patients, 19 Sep 2022
  22. News: Kraus . Yair . "Artificial intelligence is going to lead to a change the likes of which we haven't seen in years in the world of medicine" . 9 November 2023 . . 1 August 2023.
  23. News: Yanko . Adir . A significant increase in the diagnosis of young celiac patients in Israel – what are the reasons for this? . 26 October 2023 . . 25 March 2021.
  24. 10.1016/S2213-2600(22)00407-6. Safety of the fourth COVID-19 BNT162b2 mRNA (Second booster) vaccine: A prospective and retrospective cohort study. 2023. Yechezkel. Matan. Mofaz. Merav. Painsky. Amichai. Patalon. Tal. Gazit. Sivan. Shmueli. Erez. Yamin. Dan. The Lancet Respiratory Medicine. 11. 2. 139–150. 36410364. 9889528.
  25. News: Weinerb . Gali . Predicting illnesses and hospitalizations: the vision of the director of the Maccabi Research Institute . 26 October 2023 . . 1 December 2020.
  26. Danny Sullivan, Longevity AI partners with Israel’s leading HMO, Technology, 4 April 2023
  27. https://aithority.com/medical-apps/healthcare-management/ibex-introduces-galen-gastric-worlds-first-ai-powered-solution-for-gastrointestinal-cancer-diagnostics-at-maccabi-healthcare-services/ IBEX Introduces Galen Gastric, World’s First AI-Powered Solution For Gastrointestinal Cancer Diagnostics, At Maccabi Healthcare Services
  28. News: Suresh . Somasetty . New Study Shows Pfizer COVID-19 Vaccine Equally Effective for Patients with Celiac Disease . 26 October 2023 . Express Healthcare Management . 25 October 2023.
  29. https://www.ksminnovation.com/activity/biobank/ The Tipa Biobank
  30. https://www.ushealthcarejournal.com/article/586091878-ksm-research-and-innovation-and-genetika-partner-to-seek-ai-solutions-for-personalization-of-depression-treatment KSM Research And Innovation And Genetika+ Partner To Seek AI Solutions For Personalization Of Depression Treatment
  31. News: 1 February 2023 . Abu Dhabi DoH and Kahn Sagol Maccabi (KSM) Sign an MoU to Cooperate in Technological Innovation and Healthcare Research . 26 October 2023 . AP news.
  32. https://www.arabianbusiness.com/gcc/uae/g42-healthcare-ksm-enter-first-uae-israel-genetic-research-collaboration G42 Healthcare, KSM enter first UAE-Israel genetic research collaboration – Arabian Business
  33. News: Rubinstein . Carrie . 12 July 2023 . Apparently Getting Smarter Makes Us Healthier: AI And Data Analysis Revolutionize Healthcare . 26 October 2023 . Forbes.
  34. https://www.middleeastmonitor.com/20220714-israel-and-uae-to-collaborate-on-cancer-and-diabetes-research/ Israel and UAE to collaborate on cancer and diabetes research

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