| Kaffrine Region | |
| Native Name: | |
| Settlement Type: | Region |
| Image Map1: | Map of the departments of the Kaffrine region of Senegal.png |
| Map Caption1: | Kaffrine région, divided into 4 départements |
| Coordinates: | 14.1167°N -57°W |
| Subdivision Type: | Country |
| Subdivision Name: | Senegal |
| Established Title: | Established |
| Established Date: | 2008 |
| Parts Type: | Départements |
| P1: | Birkilane Department |
| P2: | Kaffrine Department |
| P3: | Koungheul Department |
| P4: | Malem Hoddar Department |
| Seat Type: | Capital |
| Seat: | Kaffrine |
| Leader Title: | Governor |
| Leader Name: | Fabackry Bodian |
| Unit Pref: | Metric |
| Area Total Km2: | 11262 |
| Population Total: | 821,287 |
| Population As Of: | 2023 census |
| Population Density Km2: | auto |
| Timezone: | GMT |
| Utc Offset: | +0 |
Kaffrine Region is a region of Senegal. It was created in 2008.
Kaffrine Region has four departments: