KYAT1 explained

Kynurenine—oxoglutarate transaminase 1 is an enzyme that in humans is encoded by the CCBL1 gene.^{[1] [2]} It is one of the Kynurenine—oxoglutarate transaminases.

This gene encodes a cytosolic enzyme which is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism leads to the formation of reactive metabolites which can lead to nephrotoxicity and neurotoxicity.

Further reading

• Cooper AJ . The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants . Neurochem. Int. . 44 . 8 . 557–77 . 2004 . 15016471 . 10.1016/j.neuint.2003.12.002 . 7643547 .
• Lash LH, Nelson RM, Van Dyke RA, Anders MW . Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity . Drug Metab. Dispos. . 18 . 1 . 50–4 . 1990 . 2139845 .
• Abraham DG, Patel PP, Cooper AJ . Isolation from rat kidney of a cytosolic high molecular weight cysteine-S-conjugate beta-lyase with activity toward leukotriene E4 . J. Biol. Chem. . 270 . 1 . 180–8 . 1995 . 7814371 . 10.1074/jbc.270.1.180 . free .
• Goldfarb P . Molecular cloning and expression of cDNAs for rat and human kidney cysteine conjugate beta-lyase . Biochem. Soc. Trans. . 24 . 2 . 330S . 1996 . 8736988 . 10.1042/bst024330s. vanc. Perry S . Harries H . 3 . Scholfield . C . Lock . T . King . L . Gibson . G .
• Iyer RA, Anders MW . Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product compound A in human, nonhuman primate, and rat kidney cytosol and mitochondria . Anesthesiology . 85 . 6 . 1454–61 . 1997 . 8968194 . 10.1097/00000542-199612000-00028 . 39394531 . free .
• Gilley J, Fried M . Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes . Hum. Mol. Genet. . 8 . 7 . 1313–20 . 1999 . 10369878 . 10.1093/hmg/8.7.1313 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Humphray SJ . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . vanc. Oliver K . Hunt AR . 3 . Plumb . R. W. . Loveland . J. E. . Howe . K. L. . Andrews . T. D. . Searle . S. . Hunt . S. E. . 2004Natur.429..369H .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Kimura K . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .
• Kapoor R . Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1) . Brain Res. . 1106 . 1 . 205–10 . 2006 . 16828464 . 10.1016/j.brainres.2006.05.082 . vanc. Lim KS . Cheng A . 3 . Garrick . Therese . Kapoor . Vimal . 42325649 .

Notes and References

1. Perry S, Harries H, Scholfield C, Lock T, King L, Gibson G, Goldfarb P . Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase . FEBS Lett . 360 . 3 . 277–80 . Apr 1995 . 7883047 . 10.1016/0014-5793(95)00123-Q . 83606450 . free .
2. Web site: Entrez Gene: CCBL1 cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase).