KRT85 explained

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.

Further reading

• Ewing RM . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . vanc. Chu P . Elisma F . 3 . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .
• Naeem M . A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type . J. Med. Genet. . 43 . 3 . 274–9 . 2006 . 16525032 . 10.1136/jmg.2005.033381 . 2563238 . vanc. Wajid M . Lee K . 3 . Leal . SM . Ahmad . W .
• Tang K, Finley RL, Nie D, Honn KV . Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening . Biochemistry . 39 . 12 . 3185–91 . 2000 . 10727209 . 10.1021/bi992664v . Finley .
• Rogers MA . Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain . J. Invest. Dermatol. . 114 . 3 . 464–72 . 2000 . 10692104 . 10.1046/j.1523-1747.2000.00910.x . vanc. Winter H . Langbein L . 3 . Wolf . Christian . Schweizer . Jürgen . free .
• Langbein L . The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle . J. Biol. Chem. . 274 . 28 . 19874–84 . 1999 . 10391933 . 10.1074/jbc.274.28.19874 . vanc. Rogers MA . Winter H . 3 . Praetzel . S . Beckhaus . U . Rackwitz . HR . Schweizer . J . free .
• Rogers MA . Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5 . J. Invest. Dermatol. . 107 . 4 . 633–8 . 1996 . 8823373 . 10.1111/1523-1747.ep12584243 . vanc. Winter H . Langbein L . 3 . Krieg . Thomas . Schweizer . Jurgen . free.

Notes and References

1. Rogers MA, Langbein L, Praetzel S, Moll I, Krieg T, Winter H, Schweizer J . Sequences and differential expression of three novel human type-II hair keratins . Differentiation . 61 . 3 . 187–94 . Apr 1997 . 9084137 . 10.1046/j.1432-0436.1997.6130187.x .
2. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . J Cell Biol . 174 . 2 . 169–74 . Jul 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
3. Web site: Entrez Gene: KRT85 keratin 85.