KRT78 explained

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.^{[1] [2]}

This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified.

Further reading

• Coulombe PA, Omary MB . 'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments . Curr. Opin. Cell Biol. . 14 . 1 . 110–22 . 2002 . 11792552 . 10.1016/S0955-0674(01)00301-5 .
• Mischke D, Wild G . Polymorphic keratins in human epidermis . J. Invest. Dermatol. . 88 . 2 . 191–7 . 1987 . 2433356 . 10.1111/1523-1747.ep12525329 .
• Rogers MA, Winter H, Langbein L, etal . Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain . J. Invest. Dermatol. . 114 . 3 . 464–72 . 2000 . 10692104 . 10.1046/j.1523-1747.2000.00910.x . free .
• Hesse M, Magin TM, Weber K . Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18 . J. Cell Sci. . 114 . Pt 14 . 2569–75 . 2002 . 10.1242/jcs.114.14.2569 . 11683385 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Hesse M, Zimek A, Weber K, Magin TM . Comprehensive analysis of keratin gene clusters in humans and rodents . Eur. J. Cell Biol. . 83 . 1 . 19–26 . 2004 . 15085952 . 10.1078/0171-9335-00354 . 11858/00-001M-0000-0012-EE54-6 . free .
• Rogers MA, Edler L, Winter H, etal . Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13 . J. Invest. Dermatol. . 124 . 3 . 536–44 . 2005 . 15737194 . 10.1111/j.0022-202X.2004.23530.x . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . J Cell Biol . 174 . 2 . 169–74 . Jul 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
2. Web site: Entrez Gene: KRT78 keratin 78.