Keratin 34 Explained

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.^{[1] [2] [3] [4]}

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription.^[4]

See also

• 34βE12 (keratin 903)

Further reading

• Yu J, Yu DW, Checkla DM, etal . Human hair keratins. . J. Invest. Dermatol. . 101 . 1 Suppl . 56S–59S . 1993 . 7686952 . 10.1111/1523-1747.ep12362635. 2024-04-03 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Raica M, Zylis D, Cîmpean AM . Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine cytology as predictors of recurrences in superficial urothelial carcinoma. . Romanian Journal of Morphology and Embryology . 46 . 1 . 11–5 . 2007 . 16286979 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Langbein L, Rogers MA, Winter H, etal . The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. . J. Biol. Chem. . 274 . 28 . 19874–84 . 1999 . 10391933 . 10.1074/jbc.274.28.19874. free .

Notes and References

1. Heid HW, Werner E, Franke WW . The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins . Differentiation . 32 . 2 . 101–19 . Feb 1987 . 2431943 . 10.1111/j.1432-0436.1986.tb00562.x .
2. Rogers MA, Winter H, Wolf C, Heck M, Schweizer J . Characterization of a 190-kilobase pair domain of human type I hair keratin genes . J Biol Chem . 273 . 41 . 26683–91 . Nov 1998 . 9756910 . 10.1074/jbc.273.41.26683. free .
3. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . J Cell Biol . 174 . 2 . 169–74 . Jul 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
4. Web site: Entrez Gene: KRT34 keratin 34.