KRT33A explained

Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the keratin gene family. It is one of the type I hair keratin genes which are clustered in a region of chromosome 17q21.2 and have the same direction of transcription. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, KRT33A (this gene) and KRT33B.

Further reading

• Yu J, Yu DW, Checkla DM, etal . Human hair keratins . J. Invest. Dermatol. . 101 . 1 Suppl . 56S–59S . 1993 . 7686952 . 10.1111/1523-1747.ep12362635 . 2024-04-03 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Rogers MA, Winter H, Langbein L, etal . The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain . Differentiation . 72 . 9–10 . 527–40 . 2005 . 15617563 . 10.1111/j.1432-0436.2004.07209006.x .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Langbein L, Rogers MA, Winter H, etal . The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle . J. Biol. Chem. . 274 . 28 . 19874–84 . 1999 . 10391933 . 10.1074/jbc.274.28.19874 . free .
• Rogers MA, Winter H, Wolf C, etal . Characterization of a 190-kilobase pair domain of human type I hair keratin genes . J. Biol. Chem. . 273 . 41 . 26683–91 . 1998 . 9756910 . 10.1074/jbc.273.41.26683 . free .

Notes and References

1. Rogers MA, Schweizer J, Kreig T, Winter H . A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms . Mol Biol Rep . 20 . 3 . 155–61 . Nov 1995 . 7565656 . 10.1007/BF00990548 . 24487602 .
2. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . J Cell Biol . 174 . 2 . 169–74 . Jul 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
3. Web site: Entrez Gene: KRT33A keratin 33A.