KRT31 explained

Keratin, type I cuticular Ha1 is a protein that in humans is encoded by the KRT31 gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of the keratin gene family. As a Type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription.^[3]

Further reading

• Yu J, Yu DW, Checkla DM, Freedberg IM, Bertolino AP . Human hair keratins . The Journal of Investigative Dermatology . 101 . 1 Suppl . 56S–59S . Jul 1993 . 7686952 . 10.1111/1523-1747.ep12362635 . 2024-04-03 .
• Dhouailly D, Xu C, Manabe M, Schermer A, Sun TT . Expression of hair-related keratins in a soft epithelium: subpopulations of human and mouse dorsal tongue keratinocytes express keratin markers for hair-, skin- and esophageal-types of differentiation . Experimental Cell Research . 181 . 1 . 141–58 . Mar 1989 . 2465162 . 10.1016/0014-4827(89)90189-4 .
• Bowden PE, Hainey S, Parker G, Hodgins MB . Sequence and expression of human hair keratin genes . Journal of Dermatological Science . 7 Suppl . S152-63 . Jul 1994 . 7528047 . 10.1016/0923-1811(94)90046-9 .
• Winter H, Hofmann I, Langbein L, Rogers MA, Schweizer J . A splice site mutation in the gene of the human type I hair keratin hHa1 results in the expression of a tailless keratin isoform . The Journal of Biological Chemistry . 272 . 51 . 32345–52 . Dec 1997 . 9405442 . 10.1074/jbc.272.51.32345 . free .
• Bowden PE, Hainey SD, Parker G, Jones DO, Zimonjic D, Popescu N, Hodgins MB . Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle . The Journal of Investigative Dermatology . 110 . 2 . 158–64 . Feb 1998 . 9457912 . 10.1046/j.1523-1747.1998.00097.x . free .
• Rogers MA, Winter H, Wolf C, Heck M, Schweizer J . Characterization of a 190-kilobase pair domain of human type I hair keratin genes . The Journal of Biological Chemistry . 273 . 41 . 26683–91 . Oct 1998 . 9756910 . 10.1074/jbc.273.41.26683 . free .
• Langbein L, Rogers MA, Winter H, Praetzel S, Beckhaus U, Rackwitz HR, Schweizer J . The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle . The Journal of Biological Chemistry . 274 . 28 . 19874–84 . Jul 1999 . 10391933 . 10.1074/jbc.274.28.19874 . free .
• Cribier B, Peltre B, Grosshans E, Langbein L, Schweizer J . On the regulation of hair keratin expression: lessons from studies in pilomatricomas . The Journal of Investigative Dermatology . 122 . 5 . 1078–83 . May 2004 . 15140206 . 10.1111/j.0022-202X.2004.22513.x . free .
• Huda Zoghbi . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Fink P, Rogers MA, Korge B, Winter H, Schweizer J . A cDNA encoding the human type I hair keratin hHal . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1264 . 1 . 12–4 . Oct 1995 . 7578244 . 10.1016/0167-4781(95)00122-w .
2. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . The Journal of Cell Biology . 174 . 2 . 169–74 . Jul 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
3. Web site: Entrez Gene: KRT31 keratin 31.