KRT23 explained

Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratin and hair keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21.

Further reading

• Suzuki A, Ji G, Numabe Y, etal . Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese . Biochem. Biophys. Res. Commun. . 317 . 3 . 887–92 . 2004 . 15081423 . 10.1016/j.bbrc.2004.03.126 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Tolstonog GV, Sabasch M, Traub P . Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function . DNA Cell Biol. . 21 . 3 . 213–39 . 2002 . 12015898 . 10.1089/10445490252925459 .
• Hesse M, Magin TM, Weber K . Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18 . J. Cell Sci. . 114 . Pt 14 . 2569–75 . 2002 . 10.1242/jcs.114.14.2569 . 11683385 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Zhang JS, Wang L, Huang H, Nelson M, Smith DI . Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells . Genes Chromosomes Cancer . 30 . 2 . 123–35 . Jan 2001 . 11135429 . 10.1002/1098-2264(2000)9999:9999<::AID-GCC1070>3.0.CO;2-W . 40237049 .
2. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . J Cell Biol . 174 . 2 . 169–74 . Jul 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
3. Web site: KRT23 keratin 23 [Homo sapiens (human) ]].