Keratin 13 Explained

Keratin 13 (or cytokeratin 13) is a protein that in humans is encoded by the KRT13 gene.^{[1] [2]}

Keratin 13 is a type I cytokeratin, it is paired with keratin 4 and found in the suprabasal layers of non-cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.^[3]

Further reading

• Jacques CM, Pereira AL, Maia V, etal . Expression of cytokeratins 10, 13, 14 and 19 in oral lichen planus . J Oral Sci . 51 . 3 . 355–65 . 2009 . 19776502 . 10.2334/josnusd.51.355 . free .
• Sheng S, Barnett DH, Katzenellenbogen BS . Differential Estradiol and Selective Estrogen Receptor Modulator (SERM) Regulation of Keratin 13 Gene Expression and its Underlying Mechanism in Breast Cancer Cells . Mol. Cell. Endocrinol. . 296 . 1–2 . 1–9 . 2008 . 18951949 . 2654210 . 10.1016/j.mce.2008.09.022 .
• Lu DP, Xing RD, Tatemoto Y, Osaki T . [Cytokeratin18, 13 and their gene expression in post-operative maxillary cyst linings with metaplastic epithelium] . Zhonghua Kou Qiang Yi Xue Za Zhi . 41 . 6 . 376–9 . 2006 . 16836912 .
• Ceratto N, Dobkin C, Carter M, etal . Human type I cytokeratin genes are a compact cluster . Cytogenet. Cell Genet. . 77 . 3–4 . 169–74 . 1997 . 9284906 . 10.1159/000134566.
• Olson GE, Winfrey VP, Blaeuer GL, etal . Stage-specific expression of the intermediate filament protein cytokeratin 13 in luminal epithelial cells of secretory phase human endometrium and peri-implantation stage rabbit endometrium . Biol. Reprod. . 66 . 4 . 1006–15 . 2002 . 11906920 . 10.1095/biolreprod66.4.1006 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3.
• Suzuki H, Fukunishi Y, Kagawa I, etal . Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs . Genome Res. . 11 . 10 . 1758–65 . 2001 . 11591653 . 311163 . 10.1101/gr.180101 .
• Rugg E, Magee G, Wilson N, etal . Identification of two novel mutations in keratin 13 as the cause of white sponge naevus . Oral Dis . 5 . 4 . 321–4 . 1999 . 10561721 . 10.1111/j.1601-0825.1999.tb00097.x .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Shibuya Y, Zhang J, Yokoo S, etal . Constitutional mutation of keratin 13 gene in familial white sponge nevus . Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 96 . 5 . 561–5 . 2003 . 14600690 . 10.1016/s1079-2104(03)00372-x.
• Terrinoni A, Rugg EL, Lane EB, etal . A novel mutation in the keratin 13 gene causing oral white sponge nevus . J. Dent. Res. . 80 . 3 . 919–23 . 2001 . 11379896 . 10.1177/00220345010800031401 . 12340591 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Waseem A, Alam Y, Dogan B, etal . Isolation, sequence and expression of the gene encoding human keratin 13 . Gene . 215 . 2 . 269–79 . 1998 . 9714826 . 10.1016/S0378-1119(98)00297-2 .
• Raspollini MR, Fambrini M, Marchionni M, etal . In situ adenocarcinoma and squamous carcinoma of uterine cervix. Pathological and immunohistochemical analysis with cytokeratin 13 . Eur. J. Obstet. Gynecol. Reprod. Biol. . 134 . 2 . 249–53 . 2007 . 16949723 . 10.1016/j.ejogrb.2006.07.047 .
• Sajjan US, Sylvester FA, Forstner JF . Cable-Piliated Burkholderia cepacia Binds to Cytokeratin 13 of Epithelial Cells . Infect. Immun. . 68 . 4 . 1787–95 . 2000 . 10722565 . 97349 . 10.1128/IAI.68.4.1787-1795.2000 .

Notes and References

1. Romano V, Raimondi E, Bosco P, Feo S, Di Pietro C, Leube RE, Troyanovsky SM, Ceratto N . Chromosomal mapping of human cytokeratin 13 gene (KRT13) . Genomics . 14 . 2 . 495–7 . October 1992 . 1385306 . 10.1016/S0888-7543(05)80250-2.
2. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW . New consensus nomenclature for mammalian keratins . J. Cell Biol. . 174 . 2 . 169–74 . July 2006 . 16831889 . 2064177 . 10.1083/jcb.200603161 .
3. Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG . Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus . Nat. Genet. . 11 . 4 . 453–5 . December 1995 . 7493031 . 10.1038/ng1295-453 . 22769768 .