| Callsign: | KMDF-LD |
| Digital: | 22 (UHF) |
| Virtual: | 22 |
| Affiliations: | 22.1: The365 (2024–present) 22.2: Cozi TV (2020–present) 22.3: Catchy Comedy 22.4: Sonlife |
| Country: | United States |
| Founded: | June 10, 2005 |
| Location: | Midland, Texas |
| Owner: | Gray Television |
| Licensee: | Gray Television Licensee, LLC |
| Sister Stations: | KOSA-TV, KCWO-TV, KWWT, KTLE-LD |
| Erp: | 15 kW |
| Haat: | 143.40NaN0 |
| Class: | LD |
| Facility Id: | 127009 |
| Coordinates: | 32.048°N -102.296°W |
| Licensing Authority: | FCC |
KMDF-LD (channel 22) is a low-power television station licensed to Midland, Texas, United States, serving the Permian Basin area as an affiliate of The365. It is owned by Gray Television alongside CBS affiliate KOSA-TV (channel 7), MyNetworkTV affiliate KWWT (channel 30), CW+ affiliate KCWO-TV (channel 4) and Telemundo affiliate KTLE-LD (channel 20). The five stations share studios inside the Music City Mall on East 42nd Street in Odessa, with a secondary studio and news bureau in downtown Midland; KTLE-LD's transmitter is located on US 385 just north of downtown Odessa.
The station's digital signal is multiplexed:
| Channel | Video | Aspect | Short name | Programming[1] |
|---|---|---|---|---|
| 22.1 | Main KMDF-LD programming / The365 | |||
| 22.2 | Cozi TV | |||
| 22.3 | Catchy Comedy | |||
| 22.4 | Sonlife |