KLK8 explained

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.^{[1] [2] [3] [4] [5]}

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.

Further reading

• Underwood LJ . Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma . Cancer Res. . 59 . 17 . 4435–9 . 1999 . 10485494 . vanc. Tanimoto H . Wang Y . 3 . Shigemasa . K . Parmley . TH . O'Brien . TJ .
• Harvey TJ . Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4 . J. Biol. Chem. . 275 . 48 . 37397–406 . 2001 . 10969073 . 10.1074/jbc.M004525200 . vanc. Hooper JD . Myers SA . 3 . Stephenson . SA . Ashworth . LK . Clements . JA . free.
• Gan L . Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region . Gene . 257 . 1 . 119–30 . 2001 . 11054574 . 10.1016/S0378-1119(00)00382-6 . vanc. Lee I . Smith R . 3 . Argonza-Barrett . R . Lei . H . McCuaig . J . Moss . P . Paeper . B . Wang . K .
• Magklara A . The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer . Clin. Cancer Res. . 7 . 4 . 806–11 . 2001 . 11309326 . vanc. Scorilas A . Katsaros D . 3 . Massobrio . M . Yousef . GM . Fracchioli . S . Danese . S . Diamandis . EP .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Clark HF . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . vanc. Gurney AL . Abaya E . 3 . Baker . K . Baldwin . D . Brush . J . Chen . J . Chow . B . Chui . C .
• Cané S . The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer . Am. J. Obstet. Gynecol. . 190 . 1 . 60–6 . 2004 . 14749636 . 10.1016/j.ajog.2003.07.020 . vanc. Bignotti E . Bellone S . 3 . Palmieri . Michela . Casas . Luis De Las . Roman . Juan J . Pecorelli . Sergio . Cannon . Martin J . O'Brien . Timothy .
• Grimwood J . The DNA sequence and biology of human chromosome 19 . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . vanc. Gordon LA . Olsen A . 3 . Terry . Astrid . Schmutz . Jeremy . Lamerdin . Jane . Hellsten . Uffe . Goodstein . David . Couronne . Olivier . 2004Natur.428..529G . free .
• Shigemasa K . Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer . Oncol. Rep. . 11 . 6 . 1153–9 . 2004 . 15138549 . 10.3892/or.11.6.1153. vanc. Tian X . Gu L . 3 . Tanimoto . H . Underwood . LJ . O'Brien . TJ . Ohama . K .
• Li Y . Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory . Mol. Biol. Evol. . 21 . 11 . 2111–5 . 2005 . 15282331 . 10.1093/molbev/msh220 . vanc. Qian YP . Yu XJ . 3 . Wang . YQ . Dong . DG . Sun . W . Ma . RM . Su . B . free .
• Rajapakse S . Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins . FEBS Lett. . 579 . 30 . 6879–84 . 2006 . 16337200 . 10.1016/j.febslet.2005.11.039 . vanc. Ogiwara K . Takano N . 3 . Moriyama . A . Takahashi . T . 2115/985 . 22439153 . free .
• Kishi T . Activation and enzymatic characterization of recombinant human kallikrein 8 . Biol. Chem. . 387 . 6 . 723–31 . 2006 . 16800733 . 10.1515/BC.2006.091 . vanc. Cloutier SM . Kündig C . 3 . Deperthes . David . Diamandis . Eleftherios P. . 19299456 .
• Sher YP . Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness . Cancer Res. . 66 . 24 . 11763–70 . 2007 . 17178872 . 10.1158/0008-5472.CAN-06-3165 . vanc. Chou CC . Chou RH . 3 . Wu . H.-M. . Wayne Chang . W.-S. . Chen . C.-H. . Yang . P.-C. . Wu . C.-W. . Yu . C.-L. . free .
• Lu ZX, Peng J, Su B . A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory . Hum. Mutat. . 28 . 10 . 978–84 . 2007 . 17487847 . 10.1002/humu.20547 . 6001199 . free .

External links

• The MEROPS online database for peptidases and their inhibitors: S01.244

Notes and References

1. Mitsui S, Tsuruoka N, Yamashiro K, Nakazato H, Yamaguchi N . A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain . Eur J Biochem . 260 . 3 . 627–34 . May 1999 . 10102990 . 10.1046/j.1432-1327.1999.00213.x . free .
2. Yoshida S, Taniguchi M, Hirata A, Shiosaka S . Sequence analysis and expression of human neuropsin cDNA and gene . Gene . 213 . 1–2 . 9–16 . Aug 1998 . 9714609 . 10.1016/S0378-1119(98)00232-7 .
3. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM . A comprehensive nomenclature for serine proteases with homology to tissue kallikreins . Biol Chem . 387 . 6 . 637–41 . Jun 2006 . 16800724 . 10.1515/BC.2006.082 . 436200 .
4. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005 . Biol Chem . 387 . 6 . 635–824 . Jun 2006 . 16800723 . 10.1515/BC.2006.081 . Diamandis . Eleftherios P. . Deperthes . David . Lundwall . Åke . 83910246 .
5. Web site: Entrez Gene: KLK8 kallikrein-related peptidase 8.