KLK2 explained

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue.^{[1] [2] [3] [4]}

Further reading

• Riegman PH . Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species . Mol. Cell. Endocrinol. . 76 . 1–3 . 181–190 . 1992 . 1726490 . 10.1016/0303-7207(91)90272-T . Vlietstra RJ . van der Korput HA . Romijn . JC . Trapman . J . 29689514 .
• Qin H . Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization . Hum. Hered. . 41 . 4 . 222–226 . 1992 . 1783409 . 10.1159/000154005 . Kemp J . Yip MY . Lam-Po-Tang . P.R.L . Morris . Brian J. .
• Schedlich LJ, Bennetts BH, Morris BJ . Primary structure of a human glandular kallikrein gene . DNA . 6 . 5 . 429–437 . 1988 . 2824146 . 10.1089/dna.1987.6.429 .
• Frenette G . Purification of enzymatically active kallikrein hK2 from human seminal plasma . Biochim. Biophys. Acta . 1334 . 1 . 109–15 . 1997 . 9042371 . 10.1016/s0304-4165(96)00080-3. Deperthes D . Tremblay RR . Lazure . C . Dubé . JY .
• Bourgeois L . Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2 . J. Biol. Chem. . 272 . 47 . 29590–29595 . 1997 . 9368023 . 10.1074/jbc.272.47.29590 . Brillard-Bourdet M . Deperthes D . Juliano . MA . Juliano . L . Tremblay . RR . Dubé . JY . Gauthier . F . free .
• Mikolajczyk SD, Millar LS, Kumar A, Saedi MS . Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors . Prostate . 34 . 1 . 44–50 . 1998 . 9428387 . 10.1002/(SICI)1097-0045(19980101)34:1<44::AID-PROS6>3.0.CO;2-K . 23179822 .
• Yu DC, Sakamoto GT, Henderson DR . Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy . Cancer Res. . 59 . 7 . 1498–504 . 1999 . 10197620 .
• Mikolajczyk SD, Millar LS, Kumar A, Saedi MS . Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1 . Int. J. Cancer . 81 . 3 . 438–442 . 1999 . 10209959 . 10.1002/(SICI)1097-0215(19990505)81:3<438::AID-IJC18>3.0.CO;2-U . free .
• Lövgren J . Measurement of prostate-specific antigen and human glandular kallikrein 2 in different body fluids . J. Androl. . 20 . 3 . 348–55 . 1999 . 10386814 . Valtonen-André C . Marsal K . Lilja . H . Lundwall . A . 10.1002/j.1939-4640.1999.tb02528.x . free .
• Cargill M . Characterization of single-nucleotide polymorphisms in coding regions of human genes . Nat. Genet. . 22 . 3 . 231–238 . 1999 . 10391209 . 10.1038/10290 . Altshuler D . Ireland J . Ireland . James . Sklar . Pamela . Ardlie . Kristin . Patil . Nila . Lane . Charles R. . Lim . Esther P. . 195213008 .
• Lövgren J, Airas K, Lilja H . Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors . Eur. J. Biochem. . 262 . 3 . 781–789 . 1999 . 10411640 . 10.1046/j.1432-1327.1999.00433.x . free .
• Mikolajczyk SD . Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue . Cancer Res. . 59 . 16 . 3927–30 . 1999 . 10463585 . Millar LS . Marker KM . Rittenhouse . HG . Wolfert . RL . Marks . LS . Charlesworth . MC . Tindall . DJ .
• Liu XF . Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing . Biochem. Biophys. Res. Commun. . 264 . 3 . 833–839 . 1999 . 10544017 . 10.1006/bbrc.1999.1595 . Essand M . Vasmatzis G . Lee . B . Pastan . I .
• Ren F . Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells . Oncogene . 19 . 15 . 1924–1932 . 2000 . 10773882 . 10.1038/sj.onc.1203511 . Zhang S . Mitchell SH . Butler . Rachel . Young . Charles YF . free .
• Harvey TJ . Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4 . J. Biol. Chem. . 275 . 48 . 37397–37406 . 2001 . 10969073 . 10.1074/jbc.M004525200 . Hooper JD . Myers SA . Stephenson . SA . Ashworth . LK . Clements . JA . free.
• Chen VC, Chao L, Chao J . A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein . J. Biol. Chem. . 275 . 51 . 40371–40377 . 2001 . 10991942 . 10.1074/jbc.M005691200 . free .
• Gan L . Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region . Gene . 257 . 1 . 119–130 . 2001 . 11054574 . 10.1016/S0378-1119(00)00382-6 . Lee I . Smith R . Argonza-Barrett . R . Lei . H . McCuaig . J . Moss . P . Paeper . B . Wang . K .
• Réhault S . Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3 . Eur. J. Biochem. . 268 . 10 . 2960–2968 . 2001 . 11358513 . 10.1046/j.1432-1327.2001.02185.x . Monget P . Mazerbourg S . Tremblay . Roland . Gutman . Ninette . Gauthier . Francis . Moreau . Thierry . free .
• Saedi MS . Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells . Int. J. Cancer . 94 . 4 . 558–563 . 2002 . 11745444 . 10.1002/ijc.1501 . Zhu Z . Marker K . Liu . Ru-Shya . Carpenter . Philip M. . Rittenhouse . Harry . Mikolajczyk . Stephen D. . 2826757 . free .

External links

• The MEROPS online database for peptidases and their inhibitors: S01.161

Notes and References

1. Riegman PH, Vlietstra RJ, Klaassen P, van der Korput JA, Geurts van Kessel A, Romijn JC, Trapman J . The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19 . FEBS Lett . 247 . 1 . 123–126 . May 1989 . 2468530 . 10.1016/0014-5793(89)81253-0 . 37763337 . free .
2. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM . A comprehensive nomenclature for serine proteases with homology to tissue kallikreins . Biol Chem . 387 . 6 . 637–641 . Jun 2006 . 16800724 . 10.1515/BC.2006.082 . 436200 .
3. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005 . Biol Chem . 387 . 6 . 635–636 . Jun 2006 . 16800723 . 10.1515/BC.2006.081 . Diamandis . Eleftherios P. . Deperthes . David . Lundwall . Åke . 83910246 .
4. Web site: Entrez Gene: KLK2 Kallikrein-related peptidase 2.