KLK11 explained

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.^{[1] [2] [3] [4] [5]}

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.

Further reading

• Mitsui S, Yamada T, Okui A, etal . A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate . Biochem. Biophys. Res. Commun. . 272 . 1 . 205–11 . 2000 . 10872828 . 10.1006/bbrc.2000.2761 .
• Gan L, Lee I, Smith R, etal . Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region . Gene . 257 . 1 . 119–30 . 2001 . 11054574 . 10.1016/S0378-1119(00)00382-6 .
• Nakamura T, Mitsui S, Okui A, etal . Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines . Prostate . 49 . 1 . 72–8 . 2002 . 11550212 . 10.1002/pros.1119 . 21572408 .
• Diamandis EP, Okui A, Mitsui S, etal . Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma . Cancer Res. . 62 . 1 . 295–300 . 2002 . 11782391 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nakamura T, Mitsui S, Okui A, etal . Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate . Prostate . 54 . 4 . 299–305 . 2003 . 12539228 . 10.1002/pros.10191 . 21482369 .
• Nakamura T, Stephan C, Scorilas A, etal . Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues . Urology . 61 . 5 . 1042–6 . 2003 . 12736044 . 10.1016/S0090-4295(02)02443-3 .
• Borgoño CA, Fracchioli S, Yousef GM, etal . Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma . Int. J. Cancer . 106 . 4 . 605–10 . 2003 . 12845660 . 10.1002/ijc.11296 . 10.1.1.623.9575 . 13671141 .
• Clark HF, Gurney AL, Abaya E, etal . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Grimwood J, Gordon LA, Olsen A, etal . The DNA sequence and biology of human chromosome 19 . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . free .
• Shigemasa K, Gu L, Tanimoto H, etal . Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer . Clin. Cancer Res. . 10 . 8 . 2766–70 . 2004 . 15102682 . 10.1158/1078-0432.CCR-03-0269 . 1192794 .
• Diamandis EP, Borgoño CA, Scorilas A, etal . Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients . Clin. Biochem. . 37 . 9 . 823–9 . 2005 . 15329323 . 10.1016/j.clinbiochem.2004.04.009 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Stavropoulou P, Gregorakis AK, Plebani M, Scorilas A . Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer . Clin. Chim. Acta . 357 . 2 . 190–5 . 2005 . 15893744 . 10.1016/j.cccn.2005.03.026 .
• Planque C, Aïnciburu M, Heuzé-Vourc'h N, etal . Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues . Biol. Chem. . 387 . 6 . 783–8 . 2006 . 16800740 . 10.1515/BC.2006.098 . 6937753 .
• Mitsui S, Nakamura T, Okui A, etal . Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin . FEBS J. . 273 . 16 . 3678–86 . 2006 . 16911518 . 10.1111/j.1742-4658.2006.05372.x . 25021929 .

External links

• The MEROPS online database for peptidases and their inhibitors: S01.257

Notes and References

1. Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S . cDNA cloning and expression of a novel serine protease, TLSP . Biochim Biophys Acta . 1399 . 2–3 . 225–8 . Oct 1998 . 9765601 . 10.1016/s0167-4781(98)00116-x.
2. Yousef GM, Scorilas A, Diamandis EP . Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family . Genomics . 63 . 1 . 88–96 . Apr 2000 . 10662548 . 10.1006/geno.1999.6072 .
3. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM . A comprehensive nomenclature for serine proteases with homology to tissue kallikreins . Biol Chem . 387 . 6 . 637–41 . Jun 2006 . 16800724 . 10.1515/BC.2006.082 . 436200 .
4. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005 . Biol Chem . 387 . 6 . 635–824 . Jun 2006 . 16800723 . 10.1515/BC.2006.081 . Diamandis . Eleftherios P. . Deperthes . David . Lundwall . Åke . 83910246 .
5. Web site: Entrez Gene: KLK11 kallikrein-related peptidase 11.