Kelch-like protein 20 explained

Kelch-like protein 20 is a protein that in humans is encoded by the KLHL20 gene.^{[1] [2]}

The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities.

Further reading

• Adams J, Kelso R, Cooley L . The kelch repeat superfamily of proteins: propellers of cell function . Trends Cell Biol. . 10 . 1 . 17–24 . 2000 . 10603472 . 10.1016/S0962-8924(99)01673-6 .
• Nemes JP . The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1) . Hum. Mol. Genet. . 9 . 10 . 1543–51 . 2000 . 10888605 . 10.1093/hmg/9.10.1543 . vanc. Benzow KA . Moseley ML . 3 . Ranum . LP . Koob . MD .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Shin BK . Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function . J. Biol. Chem. . 278 . 9 . 7607–16 . 2003 . 12493773 . 10.1074/jbc.M210455200 . vanc. Wang H . Yim AM . 3 . Le Naour . F . Brichory . F . Jang . JH . Zhao . R . Puravs . E . Tra . J . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Gregory SG . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . vanc. Barlow KF . McLay KE . 3 . Kaul . R. . Swarbreck . D. . Dunham . A. . Scott . C. E. . Howe . K. L. . Woodfine . K. . 2006Natur.441..315G . free .
• Nacak TG . The BTB-Kelch protein KLEIP controls endothelial migration and sprouting angiogenesis . Circ. Res. . 100 . 8 . 1155–63 . 2007 . 17395875 . 10.1161/01.RES.0000265844.56493.ac . vanc. Alajati A . Leptien K . 3 . Fulda . C. . Weber . H. . Miki . T. . Czepluch . F. S. . Waltenberger . J. . Wieland . T. . free .

Notes and References

1. Hara T, Ishida H, Raziuddin R, Dorkhom S, Kamijo K, Miki T . Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells . Mol Biol Cell . 15 . 3 . 1172–84 . Mar 2004 . 14668487 . 363103 . 10.1091/mbc.E03-07-0531 .
2. Web site: Entrez Gene: KLHL20 kelch-like 20 (Drosophila).