KLHDC3 explained

Kelch domain-containing protein 3 is a protein that in humans is encoded by the KLHDC3 gene.^{[1] [2]}

The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. This gene is found to express specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasm and meiotic chromatin, which suggests that this gene may be involved in meiotic recombination.^[2]

Further reading

• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Ohinata Y, Sutou S, Mitsui Y . Peas-Mea1-Ppp2r5d overlapping gene complex: a transposon mediated-gene formation in mammals. . DNA Res. . 10 . 2 . 79–84 . 2003 . 12755172 . 10.1093/dnares/10.2.79 . free .
• Ohinata Y, Sutou S, Mitsui Y . A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. . FEBS Lett. . 537 . 1–3 . 1–5 . 2003 . 12606021 . 10.1016/S0014-5793(03)00036-X . 45307604 .
• Hermey G, Keat SJ, Madsen P, etal . Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells . J. Biol. Chem. . 278 . 9 . 7390–6 . 2003 . 12482870 . 10.1074/jbc.M210851200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Ohinata Y, Sutou S, Kondo M, Takahashi T, Mitsui Y . Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis . Biol Reprod . 67 . 6 . 1824–31 . Nov 2002 . 12444059 . 10.1095/biolreprod.101.002550 . free .
2. Web site: Entrez Gene: KLHDC3 kelch domain containing 3.